TY - JOUR
T1 - Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism
AU - Piven, Joseph
AU - Berthier, Marcelo L.
AU - Starkstein, Sergio E.
AU - Nehme, Eileen
AU - Pearlson, Godfrey
AU - Folstein, Susan
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Magnetic resonance imaging (MRI) scans were performed on 13 high-functioning male autistic subjects and 13 male nonautistic control subjects comparable in age and nonverbal IQ. Scans were rated for the presence of cerebral cortical malformations. Five autistic subjects had polymicrogyria, one had schizencephaly and macrogyria, and one had macrogyria. None of the control subjects had abnormalities of this type. These abnormalities result from a defect in the migration of neurons to the cerebral cortex during the first 6 months of gestation. The detection of these malformations by MRI, their pathogenesis, and the implications regarding the pathogenesis of autism are discussed.
AB - Magnetic resonance imaging (MRI) scans were performed on 13 high-functioning male autistic subjects and 13 male nonautistic control subjects comparable in age and nonverbal IQ. Scans were rated for the presence of cerebral cortical malformations. Five autistic subjects had polymicrogyria, one had schizencephaly and macrogyria, and one had macrogyria. None of the control subjects had abnormalities of this type. These abnormalities result from a defect in the migration of neurons to the cerebral cortex during the first 6 months of gestation. The detection of these malformations by MRI, their pathogenesis, and the implications regarding the pathogenesis of autism are discussed.
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U2 - 10.1176/ajp.147.6.734
DO - 10.1176/ajp.147.6.734
M3 - Article
C2 - 2343916
AN - SCOPUS:0025315993
VL - 147
SP - 734
EP - 739
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 6
ER -