Magnetic resonance imaging correlates of dementia in multiple sclerosis

S. J. Huber, G. W. Paulson, E. C. Shuttleworth, D. Chakeres, L. E. Clapp, A. Pakalnis, K. Weiss, Kottil W Rammohan

Research output: Contribution to journalArticle

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Abstract

Thirty-two patients with clinically definite multiple sclerosis were evaluated with neuropsychological procedures and magnetic resonance imaging (MRI). Neuropsychological evaluation included assessment of language, memory, cognition, visuospatial skills, and depression. Significant impairment in any three areas, compatible with diagnosis of a dementia syndrome, was observed in 28% of these patients and lesser or no cognitive impairment characterized the remaining patients. Magnetic resonance imaging was used to evaluate the number and distribution of lesions as well as the presence of cerebral atrophy and atrophy of specific anatomic structures such as the corpus callosum. Results suggest that neither the number of lesions, the distribution of lesions, nor the extent of generalized cerebral atrophy was significantly greater in demented compared with non-demented patients. The primary finding was that atrophy of the corpus callosum was significantly more extensive on MRI scans in demented patients. Although the callosum itself may not be implicated directly in the pathogenesis of dementia, the presence of callosal atrophy on MRI scans should alert the physician to the possible occurrence of dementia in patients with multiple sclerosis.

Original languageEnglish
Pages (from-to)732-736
Number of pages5
JournalArchives of Neurology
Volume44
Issue number7
StatePublished - Aug 10 1987
Externally publishedYes

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Multiple Sclerosis
Dementia
Atrophy
Magnetic Resonance Imaging
Corpus Callosum
Cognition
Language
Depression
Physicians
Lesion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Huber, S. J., Paulson, G. W., Shuttleworth, E. C., Chakeres, D., Clapp, L. E., Pakalnis, A., ... Rammohan, K. W. (1987). Magnetic resonance imaging correlates of dementia in multiple sclerosis. Archives of Neurology, 44(7), 732-736.

Magnetic resonance imaging correlates of dementia in multiple sclerosis. / Huber, S. J.; Paulson, G. W.; Shuttleworth, E. C.; Chakeres, D.; Clapp, L. E.; Pakalnis, A.; Weiss, K.; Rammohan, Kottil W.

In: Archives of Neurology, Vol. 44, No. 7, 10.08.1987, p. 732-736.

Research output: Contribution to journalArticle

Huber, SJ, Paulson, GW, Shuttleworth, EC, Chakeres, D, Clapp, LE, Pakalnis, A, Weiss, K & Rammohan, KW 1987, 'Magnetic resonance imaging correlates of dementia in multiple sclerosis', Archives of Neurology, vol. 44, no. 7, pp. 732-736.
Huber SJ, Paulson GW, Shuttleworth EC, Chakeres D, Clapp LE, Pakalnis A et al. Magnetic resonance imaging correlates of dementia in multiple sclerosis. Archives of Neurology. 1987 Aug 10;44(7):732-736.
Huber, S. J. ; Paulson, G. W. ; Shuttleworth, E. C. ; Chakeres, D. ; Clapp, L. E. ; Pakalnis, A. ; Weiss, K. ; Rammohan, Kottil W. / Magnetic resonance imaging correlates of dementia in multiple sclerosis. In: Archives of Neurology. 1987 ; Vol. 44, No. 7. pp. 732-736.
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