Magnesium protection against anthracycline toxicity in vitro.

Martin Zdanowicz, M. A. Barletta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The clinical usefulness of the antitumour agents daunomycin (DAU) and adriamycin (ADR) is limited by their secondary cardiotoxicity. The anthracycline compounds have a number of detrimental effects on the biochemical and morphological integrity of the cardiac cell which may be related to the accumulation of cellular calcium. Using a model of spontaneously beating, cultured neonatal rat cardiomyocytes, we examined the cardioprotective role of magnesium during 2 hours of exposure to 10, 25 or 50 micrograms/ml DAU. A significant preservation of myocyte membrane integrity and cellular morphology was observed with the addition of equimolar magnesium. Magnesium opposes the actions of calcium in a number of tissues and it may be this calcium antagonist action that makes magnesium effective in DAU toxicity.

Original languageEnglish (US)
Pages (from-to)105-107
Number of pages3
JournalMagnesium research : official organ of the International Society for the Development of Research on Magnesium
Volume4
Issue number2
StatePublished - Jun 1991
Externally publishedYes

Fingerprint

Anthracyclines
Magnesium
Daunorubicin
Toxicity
Calcium
Cardiac Myocytes
Antineoplastic Agents
Doxorubicin
Muscle Cells
Rats
Tissue
Membranes
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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AB - The clinical usefulness of the antitumour agents daunomycin (DAU) and adriamycin (ADR) is limited by their secondary cardiotoxicity. The anthracycline compounds have a number of detrimental effects on the biochemical and morphological integrity of the cardiac cell which may be related to the accumulation of cellular calcium. Using a model of spontaneously beating, cultured neonatal rat cardiomyocytes, we examined the cardioprotective role of magnesium during 2 hours of exposure to 10, 25 or 50 micrograms/ml DAU. A significant preservation of myocyte membrane integrity and cellular morphology was observed with the addition of equimolar magnesium. Magnesium opposes the actions of calcium in a number of tissues and it may be this calcium antagonist action that makes magnesium effective in DAU toxicity.

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