Magnesium deficiency in the eosinophilia-myalgia syndrome: Report of clinical and biochemical improvement with repletion

Daniel J. Clauw, Kathleen Ward, Beverly Wilson, Paul Katz, Sunder S. Rajan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We describe a patient with the eosinophilia-myalgia syndrome (EMS) with persistent myalgias, cramping, and weakness that were not responsive to treatment. Despite a normal serum magnesium level, a loading study was performed, and the results suggested low tissue levels of magnesium. He was given parenteral magnesium and had dramatic improvement in symptoms as well as in muscle intracellular levels of this cation. After cessation of magnesium therapy the symptoms recurred, and magnesium repletion again led to an improvement in symptoms and ATP levels. Low tissue levels of magnesium, even in the setting of normal serum levels, may lead to the neuromuscular symptoms in EMS and related disorders.

Original languageEnglish
Pages (from-to)1331-1334
Number of pages4
JournalArthritis and Rheumatism
Volume37
Issue number9
DOIs
StatePublished - Sep 1 1994
Externally publishedYes

Fingerprint

Eosinophilia-Myalgia Syndrome
Magnesium Deficiency
Magnesium
Myalgia
Serum
Cations
Adenosine Triphosphate
Muscles
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Magnesium deficiency in the eosinophilia-myalgia syndrome : Report of clinical and biochemical improvement with repletion. / Clauw, Daniel J.; Ward, Kathleen; Wilson, Beverly; Katz, Paul; Rajan, Sunder S.

In: Arthritis and Rheumatism, Vol. 37, No. 9, 01.09.1994, p. 1331-1334.

Research output: Contribution to journalArticle

Clauw, Daniel J. ; Ward, Kathleen ; Wilson, Beverly ; Katz, Paul ; Rajan, Sunder S. / Magnesium deficiency in the eosinophilia-myalgia syndrome : Report of clinical and biochemical improvement with repletion. In: Arthritis and Rheumatism. 1994 ; Vol. 37, No. 9. pp. 1331-1334.
@article{efa02fa42a65483aa887ab16fe74d3dd,
title = "Magnesium deficiency in the eosinophilia-myalgia syndrome: Report of clinical and biochemical improvement with repletion",
abstract = "We describe a patient with the eosinophilia-myalgia syndrome (EMS) with persistent myalgias, cramping, and weakness that were not responsive to treatment. Despite a normal serum magnesium level, a loading study was performed, and the results suggested low tissue levels of magnesium. He was given parenteral magnesium and had dramatic improvement in symptoms as well as in muscle intracellular levels of this cation. After cessation of magnesium therapy the symptoms recurred, and magnesium repletion again led to an improvement in symptoms and ATP levels. Low tissue levels of magnesium, even in the setting of normal serum levels, may lead to the neuromuscular symptoms in EMS and related disorders.",
author = "Clauw, {Daniel J.} and Kathleen Ward and Beverly Wilson and Paul Katz and Rajan, {Sunder S.}",
year = "1994",
month = "9",
day = "1",
doi = "10.1002/art.1780370910",
language = "English",
volume = "37",
pages = "1331--1334",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - Magnesium deficiency in the eosinophilia-myalgia syndrome

T2 - Report of clinical and biochemical improvement with repletion

AU - Clauw, Daniel J.

AU - Ward, Kathleen

AU - Wilson, Beverly

AU - Katz, Paul

AU - Rajan, Sunder S.

PY - 1994/9/1

Y1 - 1994/9/1

N2 - We describe a patient with the eosinophilia-myalgia syndrome (EMS) with persistent myalgias, cramping, and weakness that were not responsive to treatment. Despite a normal serum magnesium level, a loading study was performed, and the results suggested low tissue levels of magnesium. He was given parenteral magnesium and had dramatic improvement in symptoms as well as in muscle intracellular levels of this cation. After cessation of magnesium therapy the symptoms recurred, and magnesium repletion again led to an improvement in symptoms and ATP levels. Low tissue levels of magnesium, even in the setting of normal serum levels, may lead to the neuromuscular symptoms in EMS and related disorders.

AB - We describe a patient with the eosinophilia-myalgia syndrome (EMS) with persistent myalgias, cramping, and weakness that were not responsive to treatment. Despite a normal serum magnesium level, a loading study was performed, and the results suggested low tissue levels of magnesium. He was given parenteral magnesium and had dramatic improvement in symptoms as well as in muscle intracellular levels of this cation. After cessation of magnesium therapy the symptoms recurred, and magnesium repletion again led to an improvement in symptoms and ATP levels. Low tissue levels of magnesium, even in the setting of normal serum levels, may lead to the neuromuscular symptoms in EMS and related disorders.

UR - http://www.scopus.com/inward/record.url?scp=0028143925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028143925&partnerID=8YFLogxK

U2 - 10.1002/art.1780370910

DO - 10.1002/art.1780370910

M3 - Article

C2 - 7945497

AN - SCOPUS:0028143925

VL - 37

SP - 1331

EP - 1334

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 9

ER -