MAG3 spect

A rapid procedure to evaluate the renal parenchyma

George N Sfakianakis, Mike Georgiou

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Renal parenchymal (cortical) scintigraphy (planar or SPECT) is indicated for the diagnosis and follow-up of focal functional disorders, such as acute pyelonephritis, and for accurate quantitation of split renal function, especially in cases of atypical location of the kidney(s). This static imaging procedure is currently performed 3-5 hr after the injection of a cortical fixation agent, (99m)Tc-DMSA or (99m)Tc-GH, and requires effective immobilization of the patient for 30 min. Methods: In five healthy adult volunteers and five children with various clinical indications, SPECT renal parenchymal scintigraphy was performed with a three-detector camera in 1-min per revolution sequential intervals for a total acquisition time of 4 min, beginning immediately after an intravenous injection of a graduated dose of 20 mCi (minimum 2 mCi) of the dynamic renal agent (99m)Tc-MAG3. Results: Tomograms of the renal parenchyma reconstructed in three projections and volume-rendered reprojection of the SPECT-volume data indicated normal or abnormal renal parenchyma. Comparisons were made with planar MAG3 end SPECT- GH and favored MAG3-SPECT. However, comparisons with DMSA indicated certain disadvantages of MAG3 SPECT. For most organs, the radiation dose estimates from 20 mCi MAG3 were lower than those from DMSA (6 mCi) or GH (20 mCi). Simultaneous injection of MAG3 and a diuretic (2-40 mg furosemide) resulted in lower than usually reported radiation dose estimates for the urinary bladder (target organ) and the gonads, and allowed subsequent evaluation of the drainage system. Conclusion: MAG3 SPECT is feasible, clinically useful and may be offered as a rapid (4 min) renal parenchymal imaging procedure, or it may precede planar dynamic (diuretic) MAG3 scintigraphy.

Original languageEnglish
Pages (from-to)478-483
Number of pages6
JournalJournal of Nuclear Medicine
Volume38
Issue number3
StatePublished - Mar 1 1997

Fingerprint

Single-Photon Emission-Computed Tomography
Kidney
Succimer
Radionuclide Imaging
Diuretics
Renal Agents
Radiation
Injections
Pyelonephritis
Furosemide
Gonads
Intravenous Injections
Immobilization
Drainage
Healthy Volunteers
Urinary Bladder

Keywords

  • Acute pyelonephritis
  • Ectopic kidney1 growth-arrested kidney
  • Renal parenchymal scintigraphy
  • SPECT
  • Split renal function
  • Technetium-99m-MAG3

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

MAG3 spect : A rapid procedure to evaluate the renal parenchyma. / Sfakianakis, George N; Georgiou, Mike.

In: Journal of Nuclear Medicine, Vol. 38, No. 3, 01.03.1997, p. 478-483.

Research output: Contribution to journalArticle

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abstract = "Renal parenchymal (cortical) scintigraphy (planar or SPECT) is indicated for the diagnosis and follow-up of focal functional disorders, such as acute pyelonephritis, and for accurate quantitation of split renal function, especially in cases of atypical location of the kidney(s). This static imaging procedure is currently performed 3-5 hr after the injection of a cortical fixation agent, (99m)Tc-DMSA or (99m)Tc-GH, and requires effective immobilization of the patient for 30 min. Methods: In five healthy adult volunteers and five children with various clinical indications, SPECT renal parenchymal scintigraphy was performed with a three-detector camera in 1-min per revolution sequential intervals for a total acquisition time of 4 min, beginning immediately after an intravenous injection of a graduated dose of 20 mCi (minimum 2 mCi) of the dynamic renal agent (99m)Tc-MAG3. Results: Tomograms of the renal parenchyma reconstructed in three projections and volume-rendered reprojection of the SPECT-volume data indicated normal or abnormal renal parenchyma. Comparisons were made with planar MAG3 end SPECT- GH and favored MAG3-SPECT. However, comparisons with DMSA indicated certain disadvantages of MAG3 SPECT. For most organs, the radiation dose estimates from 20 mCi MAG3 were lower than those from DMSA (6 mCi) or GH (20 mCi). Simultaneous injection of MAG3 and a diuretic (2-40 mg furosemide) resulted in lower than usually reported radiation dose estimates for the urinary bladder (target organ) and the gonads, and allowed subsequent evaluation of the drainage system. Conclusion: MAG3 SPECT is feasible, clinically useful and may be offered as a rapid (4 min) renal parenchymal imaging procedure, or it may precede planar dynamic (diuretic) MAG3 scintigraphy.",
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