Abstract
Objective: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2=0.38;P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 pm) was significantly less (P=.005) than in the unaffected quadrant (286 ± 27 pm). Mean RNFL thickness in the affected quadrant (89 ± 53 pm) was significantly thinner (P=.009) than in the unaffected quadrant (121 ± 39 pm). Main Outcome Measures: Mean total and quadrantic macular and RNFL thickness measurements. Conclusions: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.
| Original language | English |
|---|---|
| Pages (from-to) | 41-46 |
| Number of pages | 6 |
| Journal | Archives of Ophthalmology |
| Volume | 121 |
| Issue number | 1 |
| State | Published - Jan 1 2003 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography. / Greenfield, David; Bagga, Harmohina; Knighton, Robert W.
In: Archives of Ophthalmology, Vol. 121, No. 1, 01.01.2003, p. 41-46.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography
AU - Greenfield, David
AU - Bagga, Harmohina
AU - Knighton, Robert W.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Objective: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2=0.38;P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 pm) was significantly less (P=.005) than in the unaffected quadrant (286 ± 27 pm). Mean RNFL thickness in the affected quadrant (89 ± 53 pm) was significantly thinner (P=.009) than in the unaffected quadrant (121 ± 39 pm). Main Outcome Measures: Mean total and quadrantic macular and RNFL thickness measurements. Conclusions: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.
AB - Objective: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2=0.38;P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 pm) was significantly less (P=.005) than in the unaffected quadrant (286 ± 27 pm). Mean RNFL thickness in the affected quadrant (89 ± 53 pm) was significantly thinner (P=.009) than in the unaffected quadrant (121 ± 39 pm). Main Outcome Measures: Mean total and quadrantic macular and RNFL thickness measurements. Conclusions: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.
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M3 - Article
C2 - 12523883
AN - SCOPUS:0037248250
VL - 121
SP - 41
EP - 46
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 1
ER -