Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography

David Greenfield, Harmohina Bagga, Robert W. Knighton

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158 Citations (Scopus)

Abstract

Objective: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2=0.38;P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 pm) was significantly less (P=.005) than in the unaffected quadrant (286 ± 27 pm). Mean RNFL thickness in the affected quadrant (89 ± 53 pm) was significantly thinner (P=.009) than in the unaffected quadrant (121 ± 39 pm). Main Outcome Measures: Mean total and quadrantic macular and RNFL thickness measurements. Conclusions: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalArchives of Ophthalmology
Volume121
Issue number1
StatePublished - Jan 1 2003

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Optic Nerve Diseases
Optical Coherence Tomography
Nerve Fibers
Visual Fields
Glaucoma
Visual Field Tests
Retinal Ganglion Cells
Visual Acuity
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography. / Greenfield, David; Bagga, Harmohina; Knighton, Robert W.

In: Archives of Ophthalmology, Vol. 121, No. 1, 01.01.2003, p. 41-46.

Research output: Contribution to journalArticle

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abstract = "Objective: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (R2 = 0.47; P<.001), pattern standard deviation (R2 = 0.32; P<.001), and mean RNFL thickness (R2=0.38;P<.001). In glaucomatous eyes with visual field loss localized to 1 hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 pm) was significantly less (P=.005) than in the unaffected quadrant (286 ± 27 pm). Mean RNFL thickness in the affected quadrant (89 ± 53 pm) was significantly thinner (P=.009) than in the unaffected quadrant (121 ± 39 pm). Main Outcome Measures: Mean total and quadrantic macular and RNFL thickness measurements. Conclusions: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.",
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