Macular retinal sublayer thicknesses in G11778A leber hereditary optic neuropathy

Byron L Lam, Samuel P. Burke, Mindy X. Wang, Gloria A. Nadayil, Potyra R. Rosa, Giovanni Gregori, William J Feuer, Sophia Cuprill-Nilson, Ruth Vandenbroucke, Xiaojun Zhang, John Guy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To determine macular retinal sublayer thickness changes in G11778A Leber hereditary optic neuropathy (LHON). PATIENTS AND METHODS: The authors performed a crosssectional study by segmenting spectral-domain Cirrus OCT (Carl Zeiss Meditec, Dublin, CA) 512 × 128 macular cube scans from a prospective, observational study of G11778A LHON. The thickness of the retinal sublayers of LHON affected subjects and asymptomatic carriers were compared to those of a normal group. RESULTS: The study included 20 LHON-affected subjects (13 males; age: 31 years ± 14 years, range: 10 years to 61 years; time since onset of visual loss: 5.9 years ± 8.7 years; 0.4-29.8), 31 asymptomatic LHON carriers (five males; age: 38 years ± 18 years, range: 9 years to 65 years), and 14 normal subjects (five males; age: 39 years ± 13 years, range: 23 years to 61 years). The retinal sublayer thickness parameters were not significantly correlated with age in any of the groups. There were no differences between carriers and normal subjects for thickness of total retina or any sublayer. Affected LHON retinal nerve fiber layer (RNFL) and ganglion cell layer plus inner plexiform layer (GCL+IPL) were thinner, whereas the photoreceptor outer segment (OS) layer was thicker than carriers and normal subjects (P values ranged from .042 to < .001), except for the OS layer in the inferior inner ring and temporal outer ring. Differences between groups were not significant in the inner nuclear layer plus outer plexiform layer (INL+OPL). The affected LHON outer nuclear layer plus inner segment layer was thicker in some quadrants, and the affected LHON choroid layer was generally thinner than carriers and normal subjects; however, these differences were not significant after accounting for age. CONCLUSION: LHON-affected patients have thickened photoreceptor OS layers in spite of having thinner RNFL and GCL+IPL layers. The findings indicate LHON also has an effect on the morphology of the photoreceptors.

Original languageEnglish (US)
Pages (from-to)802-810
Number of pages9
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume47
Issue number9
DOIs
StatePublished - Sep 1 2016

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Leber's Hereditary Optic Atrophy
Nerve Fibers
Choroid
Ganglia
Observational Studies
Retina

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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Macular retinal sublayer thicknesses in G11778A leber hereditary optic neuropathy. / Lam, Byron L; Burke, Samuel P.; Wang, Mindy X.; Nadayil, Gloria A.; Rosa, Potyra R.; Gregori, Giovanni; Feuer, William J; Cuprill-Nilson, Sophia; Vandenbroucke, Ruth; Zhang, Xiaojun; Guy, John.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 47, No. 9, 01.09.2016, p. 802-810.

Research output: Contribution to journalArticle

Lam, BL, Burke, SP, Wang, MX, Nadayil, GA, Rosa, PR, Gregori, G, Feuer, WJ, Cuprill-Nilson, S, Vandenbroucke, R, Zhang, X & Guy, J 2016, 'Macular retinal sublayer thicknesses in G11778A leber hereditary optic neuropathy', Ophthalmic Surgery Lasers and Imaging Retina, vol. 47, no. 9, pp. 802-810. https://doi.org/10.3928/23258160-20160901-02
Lam, Byron L ; Burke, Samuel P. ; Wang, Mindy X. ; Nadayil, Gloria A. ; Rosa, Potyra R. ; Gregori, Giovanni ; Feuer, William J ; Cuprill-Nilson, Sophia ; Vandenbroucke, Ruth ; Zhang, Xiaojun ; Guy, John. / Macular retinal sublayer thicknesses in G11778A leber hereditary optic neuropathy. In: Ophthalmic Surgery Lasers and Imaging Retina. 2016 ; Vol. 47, No. 9. pp. 802-810.
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abstract = "BACKGROUND AND OBJECTIVE: To determine macular retinal sublayer thickness changes in G11778A Leber hereditary optic neuropathy (LHON). PATIENTS AND METHODS: The authors performed a crosssectional study by segmenting spectral-domain Cirrus OCT (Carl Zeiss Meditec, Dublin, CA) 512 × 128 macular cube scans from a prospective, observational study of G11778A LHON. The thickness of the retinal sublayers of LHON affected subjects and asymptomatic carriers were compared to those of a normal group. RESULTS: The study included 20 LHON-affected subjects (13 males; age: 31 years ± 14 years, range: 10 years to 61 years; time since onset of visual loss: 5.9 years ± 8.7 years; 0.4-29.8), 31 asymptomatic LHON carriers (five males; age: 38 years ± 18 years, range: 9 years to 65 years), and 14 normal subjects (five males; age: 39 years ± 13 years, range: 23 years to 61 years). The retinal sublayer thickness parameters were not significantly correlated with age in any of the groups. There were no differences between carriers and normal subjects for thickness of total retina or any sublayer. Affected LHON retinal nerve fiber layer (RNFL) and ganglion cell layer plus inner plexiform layer (GCL+IPL) were thinner, whereas the photoreceptor outer segment (OS) layer was thicker than carriers and normal subjects (P values ranged from .042 to < .001), except for the OS layer in the inferior inner ring and temporal outer ring. Differences between groups were not significant in the inner nuclear layer plus outer plexiform layer (INL+OPL). The affected LHON outer nuclear layer plus inner segment layer was thicker in some quadrants, and the affected LHON choroid layer was generally thinner than carriers and normal subjects; however, these differences were not significant after accounting for age. CONCLUSION: LHON-affected patients have thickened photoreceptor OS layers in spite of having thinner RNFL and GCL+IPL layers. The findings indicate LHON also has an effect on the morphology of the photoreceptors.",
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AU - Rosa, Potyra R.

AU - Gregori, Giovanni

AU - Feuer, William J

AU - Cuprill-Nilson, Sophia

AU - Vandenbroucke, Ruth

AU - Zhang, Xiaojun

AU - Guy, John

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N2 - BACKGROUND AND OBJECTIVE: To determine macular retinal sublayer thickness changes in G11778A Leber hereditary optic neuropathy (LHON). PATIENTS AND METHODS: The authors performed a crosssectional study by segmenting spectral-domain Cirrus OCT (Carl Zeiss Meditec, Dublin, CA) 512 × 128 macular cube scans from a prospective, observational study of G11778A LHON. The thickness of the retinal sublayers of LHON affected subjects and asymptomatic carriers were compared to those of a normal group. RESULTS: The study included 20 LHON-affected subjects (13 males; age: 31 years ± 14 years, range: 10 years to 61 years; time since onset of visual loss: 5.9 years ± 8.7 years; 0.4-29.8), 31 asymptomatic LHON carriers (five males; age: 38 years ± 18 years, range: 9 years to 65 years), and 14 normal subjects (five males; age: 39 years ± 13 years, range: 23 years to 61 years). The retinal sublayer thickness parameters were not significantly correlated with age in any of the groups. There were no differences between carriers and normal subjects for thickness of total retina or any sublayer. Affected LHON retinal nerve fiber layer (RNFL) and ganglion cell layer plus inner plexiform layer (GCL+IPL) were thinner, whereas the photoreceptor outer segment (OS) layer was thicker than carriers and normal subjects (P values ranged from .042 to < .001), except for the OS layer in the inferior inner ring and temporal outer ring. Differences between groups were not significant in the inner nuclear layer plus outer plexiform layer (INL+OPL). The affected LHON outer nuclear layer plus inner segment layer was thicker in some quadrants, and the affected LHON choroid layer was generally thinner than carriers and normal subjects; however, these differences were not significant after accounting for age. CONCLUSION: LHON-affected patients have thickened photoreceptor OS layers in spite of having thinner RNFL and GCL+IPL layers. The findings indicate LHON also has an effect on the morphology of the photoreceptors.

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