Macular ganglion cell-inner plexiform layer: Automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma

Jean Claude Mwanza, Jonathan D. Oakley, Donald L. Budenz, Robert T. Chang, O'Rese J. Knight, William J Feuer

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Purpose. To demonstrate the capability of SD-OCT to measure macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness and to assess its reproducibility in glaucomatous eyes. Methods. Fifty-one glaucomatous eyes (26 mild, 11 moderate, 14 severe) of 51 patients underwent macular scanning using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) macula 200×200 acquisition protocol. Five scans were obtained on 5 days within 2 months. The ganglion cell analysis (GCA) algorithm was used to detect the macular GCIPL and to measure the thickness of the overall average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL. The reproducibility of the measurements was evaluated with intraclass correlation coefficients (ICCs), coefficients of variation (COVs), and test-retest standard deviations (TRTSDs). Results. Segmentation and measurement of GCIPL thickness were successful in 50 of 51 subjects. All ICCs ranged between 0.94 and 0.98, but ICCs for average and superior GCIPL parameters (0.97-0.98) were slightly higher than for inferior GCIPL parameters (0.94-0.97). All COVs were

Original languageEnglish (US)
Pages (from-to)8323-8329
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number11
DOIs
StatePublished - Oct 2011

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Optical Coherence Tomography
Ganglia
Glaucoma
Retinal Ganglion Cells

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Macular ganglion cell-inner plexiform layer : Automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma. / Mwanza, Jean Claude; Oakley, Jonathan D.; Budenz, Donald L.; Chang, Robert T.; Knight, O'Rese J.; Feuer, William J.

In: Investigative Ophthalmology and Visual Science, Vol. 52, No. 11, 10.2011, p. 8323-8329.

Research output: Contribution to journalArticle

Mwanza, Jean Claude ; Oakley, Jonathan D. ; Budenz, Donald L. ; Chang, Robert T. ; Knight, O'Rese J. ; Feuer, William J. / Macular ganglion cell-inner plexiform layer : Automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma. In: Investigative Ophthalmology and Visual Science. 2011 ; Vol. 52, No. 11. pp. 8323-8329.
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