Macular electroretinograms to flicker and pattern stimulation in lamellar macular holes

Benedetto Falsini, Angelo Minnella, Luca Buzzonetti, Erasmo Merendino, Vittorio Porciatti

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Steady-state macular (9° × 9°) electroretinograms in response to either sinusoidal flicker (focal electroretinogram) or counterphased sinusoidal gratings (pattern electroretinogram) were recorded in 14 patients with inner lamellar macular holes, in 4 patients with full-thickness macular holes and in 14 age-matched controls. Fourier analysis of focal and pattern electroretinograms yielded three main components: a first and a second harmonic to flicker, and a second harmonic to pattern. Recent evidence indicates that the first harmonic to flicker is of receptoral origin, whereas the flicker and pattern second harmonics represent, at least in part, the activity of different generators in the inner retina. When compared to controls, patients with inner lamellar holes showed significant amplitude reduction and phase delay for both flicker and pattern second harmonics, but not for the flicker first harmonic. Patients with full-thickness holes showed significant amplitude reduction also for the flicker first harmonic. These results indicate a prevalent functional involvement of the inner retina in lamellar macular holes, which can be clinically detected by evaluating focal and pattern electroretinogram second harmonics.

Original languageEnglish (US)
Pages (from-to)99-108
Number of pages10
JournalDocumenta Ophthalmologica
Volume79
Issue number2
DOIs
StatePublished - Jun 1 1992
Externally publishedYes

Keywords

  • Focal electroretinogram
  • lamellar macular holes
  • pattern electroretinogram
  • steadystate analysis

ASJC Scopus subject areas

  • Ophthalmology

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