Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Donatello Castellana, Ralf Paus, Mirna Perez-Moreno

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.

Original languageEnglish (US)
Article numbere1002002
JournalPLoS Biology
Volume12
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

hair follicles
Hair Follicle
Macrophages
Stem cells
stem cells
Skin
macrophages
Stem Cells
skin (animal)
Chemical activation
epithelial cells
apoptosis
Epithelial Cells
Apoptosis
skin diseases
Skin Neoplasms
Transcription
Skin Diseases
Gene expression
Hair

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells. / Castellana, Donatello; Paus, Ralf; Perez-Moreno, Mirna.

In: PLoS Biology, Vol. 12, No. 12, e1002002, 01.01.2014.

Research output: Contribution to journalArticle

Castellana, Donatello ; Paus, Ralf ; Perez-Moreno, Mirna. / Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells. In: PLoS Biology. 2014 ; Vol. 12, No. 12.
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