Macrophages and HIV-1: An Unhealthy Constellation

Quentin J. Sattentau, Mario Stevenson

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalCell Host and Microbe
Volume19
Issue number3
DOIs
StatePublished - Mar 9 2016

Fingerprint

HIV-1
Macrophages
Primate Lentiviruses
Lentivirus
Infection
Therapeutics

Keywords

  • HIV-1
  • macrophage
  • pathogenesis
  • reservoir

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Macrophages and HIV-1 : An Unhealthy Constellation. / Sattentau, Quentin J.; Stevenson, Mario.

In: Cell Host and Microbe, Vol. 19, No. 3, 09.03.2016, p. 304-310.

Research output: Contribution to journalArticle

Sattentau, Quentin J. ; Stevenson, Mario. / Macrophages and HIV-1 : An Unhealthy Constellation. In: Cell Host and Microbe. 2016 ; Vol. 19, No. 3. pp. 304-310.
@article{97436df4d90c4b2aa8463a51088d6a6e,
title = "Macrophages and HIV-1: An Unhealthy Constellation",
abstract = "Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.",
keywords = "HIV-1, macrophage, pathogenesis, reservoir",
author = "Sattentau, {Quentin J.} and Mario Stevenson",
year = "2016",
month = "3",
day = "9",
doi = "10.1016/j.chom.2016.02.013",
language = "English (US)",
volume = "19",
pages = "304--310",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Macrophages and HIV-1

T2 - An Unhealthy Constellation

AU - Sattentau, Quentin J.

AU - Stevenson, Mario

PY - 2016/3/9

Y1 - 2016/3/9

N2 - Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

AB - Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

KW - HIV-1

KW - macrophage

KW - pathogenesis

KW - reservoir

UR - http://www.scopus.com/inward/record.url?scp=84961827253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961827253&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2016.02.013

DO - 10.1016/j.chom.2016.02.013

M3 - Article

C2 - 26962941

AN - SCOPUS:84961827253

VL - 19

SP - 304

EP - 310

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 3

ER -