Macrophages and HIV-1: An Unhealthy Constellation

Quentin J. Sattentau, Mario Stevenson

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalCell Host and Microbe
Volume19
Issue number3
DOIs
StatePublished - Mar 9 2016

Keywords

  • HIV-1
  • macrophage
  • pathogenesis
  • reservoir

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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