Macrophage migration inhibition and lymphocyte stimulation with mammary tumor virus associated antigens in Balb/c mice

Diana M Lopez, G. Ortiz Muniz, M. M. Sigel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Lymphocytes of MTV (mammary tumor virus) negative Balb/c mice are sensitive to one or more antigens of MTV as determined by blastogenic transformation and migration inhibition assays. The lymphocytes from MTV positive Balb/cfC3H mice are nonresponsive in these assays but become responsive after the mice have been implanted with MTV positive tumors. The latter findings imply that there may be either a state of tolerance to MTV antigens which is broken by the tumor transplant or that the responses are directed towards antigens to which the host is not tolerant. The cause of the sensitivity of lymphocytes from MTV negative Balb/c mice to MTV antigens has not been determined but two possible explanations are discussed: horizontal transmission and depression of genetic information for viral antigen.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume151
Issue number1
StatePublished - Dec 1 1976

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Oncogenic Viruses
Lymphocytes
Macrophages
Lymphocyte Activation
Viruses
Tumors
Breast Neoplasms
Antigens
Neoplasm Antigens
Mouse mammary tumor virus
Viral Antigens
Assays
Neoplasms
Transplants

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Macrophage migration inhibition and lymphocyte stimulation with mammary tumor virus associated antigens in Balb/c mice. / Lopez, Diana M; Ortiz Muniz, G.; Sigel, M. M.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 151, No. 1, 01.12.1976, p. 225-230.

Research output: Contribution to journalArticle

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