Macrophage Migration Inhibition and Lymphocyte Stimulation with Mammary Tumor Virus Associated Antigens in Balb/c Mice

Diana M. Lopez, Gabriel Ortiz-Muniz, M. Michael Sigel

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Abstract

Lymphocytes of MTV (mammary tumor virus) negative Balb/c mice are sensitive to one or more antigens of MTV as determined by blastogenic transformation and migration inhibition assays. The lymphocytes from MTV positive Balb/cfC3H mice are nonresponsive in these assays but become responsive after the mice have been implanted with MTV positive tumors. The latter findings imply that there may be either a state of tolerance to MTV antigens which is broken by the tumor transplant or that the responses are directed towards antigens to which the host is not tolerant. The cause of the sensitivity of lymphocytes from MTV negative Balb/c mice to MTV antigens has not been determined but two possible explanations are discussed: horizontal transmission and depression of genetic information for viral antigen.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume151
Issue number1
DOIs
StatePublished - Jan 1976

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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