Macrophage Involvement in the Protective Effect of Pyran Copolymer against the Madison Lung Carcinoma (M109)

Richard M. Schultz, Joseph D. Papamatheakis, Josef Luetzeler, Phillip Ruiz, Michael A. Chirigos

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Pyran copolymer (NSC 46015) therapy markedly enhanced host resistance to a murine lung carcinoma (M109) implanted s.c. Multiple dose schedules were not significantly better than single doses at increasing lifespan. Although tumor necrosis was much more extensive in the lesions of pyran treated mice, pyran copolymer was not directly toxic to M109 cells in vitro. A comparative histopathological study revealed an intense histiocytic reaction in the connective tissue surrounding the primary tumor in mice receiving pyran as compared to 0.9% NaCl solution treated controls. Macrophages were often associated with necrobiotic tumor cells. Morphologically activated macrophages were recovered from pyran treated animals which potently inhibited DNA synthesis of M109 tumor cells in vitro. This response peaked 6 days after drug treatment and was to large extent specific for neoplastic cells. Our results from both in vivo and in vitro studies support the concept that pyran enhances host resistance to neoplasia by mobilization and activation of the reticuloendothelial elements of the host's defense.

Original languageEnglish (US)
Pages (from-to)358-364
Number of pages7
JournalCancer Research
Volume37
Issue number2
StatePublished - Feb 1977
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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