Macrophage inflammatory protein-2, neutrophil recruitment and bacterial persistence in an experimental mouse model of urinary tract infection

Rahul Mittal, Sanjay Chhibber, Saroj Sharma, Kusum Harjai

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

This study analyzed macrophage inflammatory protein-2 (MIP-2) production and neutrophil recruitment in urinary tract in response to Pseudomonas aeruginosa in an ascending model of urinary tract infection (UTI) in mice. Both planktonic and biofilm cells of P. aeruginosa were used for inducing UTI in mice. MIP-2 levels determined in urine, bladder and kidney showed maximum MIP-2 production 6:h postinfection, which correlated with neutrophil recruitment. Biofilm cells showed significantly more MIP-2 production and neutrophil recruitment. However, no correlation between bacterial numbers and neutrophil recruitment was observed in urine and kidney tissue. The role of MIP-2 and neutrophils in relation to the persistence of P. aeruginosa in the urinary tract of mice is discussed.

Original languageEnglish (US)
Pages (from-to)1326-1332
Number of pages7
JournalMicrobes and Infection
Volume6
Issue number14
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • Macrophage inflammatory protein
  • Mouse model
  • Neutrophil recruitment
  • Pseudomonas aeruginosa
  • Urinary tract infection

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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