M proteins of group G streptococci: Mechanisms of resistance to phagocytosis

Rafael E Campo, D. R. Schultz, A. L. Bisno

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Group G streptococci that express M protein and resist phagocytosis in human blood (virulent strains) were compared with strains of groups G and A that are readily phagocytosed (avirulent). Virulent group G streptococci were less effective (P < .05) as activators of the alternative complement pathway (ACP) than were avirulent streptococci. In immunofluorescence studies, C3 bound more avidly to avirulent than to virulent group G streptococci. Resistance of virulent group G strains to ACP opsonization and to phagocytosis was markedly diminished by removal with pepsin of the type- specific portion of the M molecule. Preincubation with fibrinogen did not diminish ACP activation or C3 binding by virulent group G and A streptococci but did exert an antiphagocytic effect. Given the similarity of M proteins of groups G and A in structure and function, other microbial constituents are likely responsible for differences in the spectra of illnesses attributable to the two serogroups.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalJournal of Infectious Diseases
Volume171
Issue number3
StatePublished - Jan 1 1995

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Streptococcus
Phagocytosis
Alternative Complement Pathway
Complement C3
Pepsin A
Fibrinogen
Fluorescent Antibody Technique
Proteins
Streptococcus IgG Fc-binding protein

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Campo, R. E., Schultz, D. R., & Bisno, A. L. (1995). M proteins of group G streptococci: Mechanisms of resistance to phagocytosis. Journal of Infectious Diseases, 171(3), 601-606.

M proteins of group G streptococci : Mechanisms of resistance to phagocytosis. / Campo, Rafael E; Schultz, D. R.; Bisno, A. L.

In: Journal of Infectious Diseases, Vol. 171, No. 3, 01.01.1995, p. 601-606.

Research output: Contribution to journalArticle

Campo, RE, Schultz, DR & Bisno, AL 1995, 'M proteins of group G streptococci: Mechanisms of resistance to phagocytosis', Journal of Infectious Diseases, vol. 171, no. 3, pp. 601-606.
Campo, Rafael E ; Schultz, D. R. ; Bisno, A. L. / M proteins of group G streptococci : Mechanisms of resistance to phagocytosis. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 3. pp. 601-606.
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