Lysyl oxidase in development, aging and pathologies of the skin

Kornelia Molnarne Szauter, Tongyu Wikramanayake, Charles D. Boyd, Katalin Csiszar

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Lysyl oxidase (LOX) is a copper- and lysyl-tyrosyl cofactor containing amine oxidase that has been known to play a critical role in the catalysis of lysine-derived crosslinks in extracellular matrix (ECM) proteins in the dermis. Changes in the composition and crosslinked state of the ECM and alterations in LOX synthesis and activity are known to be associated with aging and a range of acquired and heritable skin disorders. It has been assumed until recently that the LOX-related changes in the skin are mediated through the catalytic activity of LOX. However, work by several laboratories over the last few years has shown that LOX is a multifunctional protein. In this review we discuss the regulation of expression, localization and activation of LOX in the normal developing and adult skin, and alterations in LOX expression and activity associated with skin aging and senescence, and in pathological conditions, including wound healing, fibrosis, hypertrophic scarring, keloids, scleroderma, and diabetic skin. We further evaluate the role of LOX in skin ECM changes associated with the normal aging process and with these pathological states. In addition to collagen and elastin cross-linkages, regulatory and activation mechanisms and cell type specific LOX interactions may contribute to a range of novel intra- and extracellular LOX functions that appear critical determinants of the cellular microenvironment in the normal skin and in these skin disorders.

Original languageEnglish
Pages (from-to)448-456
Number of pages9
JournalPathologie Biologie
Volume53
Issue number7
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

Fingerprint

Protein-Lysine 6-Oxidase
Skin Aging
Pathology
Skin
Aging of materials
Extracellular Matrix
Chemical activation
Cellular Microenvironment
Keloid
Elastin
Extracellular Matrix Proteins
Pathologic Processes
Dermis
Catalysis
Wound Healing
Lysine
Amines
Cicatrix
Copper
Catalyst activity

Keywords

  • Aging
  • Lysyl oxidase
  • Skin diseases

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Lysyl oxidase in development, aging and pathologies of the skin. / Szauter, Kornelia Molnarne; Wikramanayake, Tongyu; Boyd, Charles D.; Csiszar, Katalin.

In: Pathologie Biologie, Vol. 53, No. 7, 01.09.2005, p. 448-456.

Research output: Contribution to journalArticle

Szauter, Kornelia Molnarne ; Wikramanayake, Tongyu ; Boyd, Charles D. ; Csiszar, Katalin. / Lysyl oxidase in development, aging and pathologies of the skin. In: Pathologie Biologie. 2005 ; Vol. 53, No. 7. pp. 448-456.
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