Lymphovascular invasion in radical cystectomy specimen: Is it an independent prognostic factor in patients without lymph node metastases?

Murugesan Manoharan, Devendar Katkoori, T. A. Kishore, Merce Jorda, Tony Luongo, Mark S. Soloway

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose: To determine the prognostic significance of lymphovascular invasion (LVI) in patients with urothelial carcinoma of the bladder undergoing radical cystectomy (RC) and bilateral pelvic lymph node dissection. Methods: From 1992 to 2008, 526 patients underwent RC and pelvic lymphadenectomy at our institution by a single surgical team. All relevant data were entered into a database and analyzed. LVI was defined as "the presence of tumor cells within an endothelial lined space." The exclusion criteria were non-TCC histology, salvage cystectomy, neoadjuvant chemotherapy, and unknown LVI status. Results: A total of 357 patients met the inclusion criteria. Overall prevalence of LVI was 29%. LVI was significantly associated with higher T stage, lymph node (LN) metastases, and higher grade. Patients with LVI had significantly higher recurrence rate (P < 0.001) and decreased long-term survival (P < 0.001). In patients without LN metastases, LVI in the primary led to a significantly decreased recurrence-free (P = 0.003) and disease-specific survival (P = 0.001). In the presence of LN metastases, LVI did not significantly alter the recurrence-free or disease-specific survival. On multivariate analysis, T stage (P < 0.0001) and LN metastases (P = 0.01) were significant independent prognostic factors influencing disease-specific survival. LVI did not have independent prognostic value. T stage was the only significant prognostic factor in the lymph node negative group. Conclusions: Although, the presence of LVI in node-negative patients is an adverse prognostic factor on univariate analysis of disease-specific survival, it is not an independent prognostic factor on multivariate analysis. Pathological stage is the only independent prognostic factor for survival.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalWorld journal of urology
Issue number2
StatePublished - 2010


  • Bladder cancer
  • Lymph node negative
  • Lymphovascular invasion
  • Prognosis
  • Radical cystectomy

ASJC Scopus subject areas

  • Urology


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