Lymphoproliferative responses to mouse mammary tumor virus in lymphocyte subsets of breast cancer patients

Diana M Lopez, W. P. Parks, M. A. Silverman, J. A. Distasio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Altered immunologic reactions were observed in breast cancer patients as compared to those in normal subjects. Lymphoproliferative responses to murine mammary tumor virus (MuMTV) were significantly enhanced in peripheral blood mononuclear cells from patients with metastatic disease. These reactivities occurred with mammary tumor virus purified from either mouse milk or infected feline kidney cells but not with Rauscher murine leukemia virus. For the assessment of the role of peripheral blood mononuclear leukocyte subpopulations in the responsiveness to MuMTV, the cell preparations were fractionated according to their ability to form spontaneous rosettes with sheep red blood cells (E-rosettes). The effectiveness of the separation was ascertained by means of cell surface markers, i.e., presence of surface immunoglobulins or a T-cell marker, Leu-1 antigen, and mitogen-induced blastogenesis. The responsiveness to the MuMTV antigen(s) was associated with the T-cell subset, identified as the E-rosetting, Leu-1-positive, and surface immunoglobulin-negative population. Although some subjects with the normal population gave positive reactions, the results reveal an apparent association between high levels of responsiveness to MuMTV within the T-lymphocyte subset and breast cancer disease.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalJournal of the National Cancer Institute
Volume67
Issue number2
StatePublished - Jan 1 1981

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Mouse mammary tumor virus
Lymphocyte Subsets
Gammaretrovirus
Breast Neoplasms
B-Cell Antigen Receptors
T-Lymphocyte Subsets
CD5 Antigens
Rauscher Virus
Mononuclear Leukocytes
Murine Leukemia Viruses
Oncogenic Viruses
Breast Diseases
Felidae
Neoplasm Antigens
Lymphocyte Activation
Mitogens
Population
Blood Cells
Sheep
Milk

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lymphoproliferative responses to mouse mammary tumor virus in lymphocyte subsets of breast cancer patients. / Lopez, Diana M; Parks, W. P.; Silverman, M. A.; Distasio, J. A.

In: Journal of the National Cancer Institute, Vol. 67, No. 2, 01.01.1981, p. 353-358.

Research output: Contribution to journalArticle

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