Lymphoproliferative disorders of the kidney on fine-needle aspiration

Cytomorphology and radiographic correlates in 33 cases

Andrea P. Subhawong, Ty Subhawong, Christopher J. Vandenbussche, Momin T. Siddiqui, Syed Z. Ali

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Unless renal lesions present in the setting of widespread lymphoma, biopsy can be indicated to differentiate from metastases, hypovascular renal cell carcinoma, urothelial carcinoma or infection. We review our experience with lymphoproliferative disorders in the kidney diagnosed by fine-needle aspiration (FNA), and focus on clinicopathologic and radiographic features. Design: All cases of non-Hodgkin lymphoma diagnosed on renal FNA at 2 academic institutions between 1989 and 2011 were reviewed. Clinical history, radiographic and cytomorphologic features, and follow-up were assessed. Results: 33 cases were identified, with 15 primary tumors and 18 recurrences/secondary tumors including 1 acute lymphoblastic lymphoma. The majority were aggressive/high-grade lesions (25/33). 25 cases were substantiated by positive flow cytometry results. Most were detected at follow-up/incidentally. 22 cases showed multiple renal and/or retroperitoneal masses or a significant component of adenopathy; others showed a solitary renal mass. Salient radiologic features included hypodense, infiltrative and ill-defined masses. Cytomorphology showed a monotonous population of large atypical lymphoid cells, often with lymphoglandular bodies. Conclusion: Cytologic diagnosis of renal lymphoma requires analysis of morphological, clinical and immunophenotypic information. Helpful features for diagnosis include: multiple masses on computed tomography, a monotonous population of abnormal cells in a background of lymphoglandular bodies and immunophenotyping demonstrating light chain restriction.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalActa Cytologica
Volume57
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Lymphoproliferative Disorders
Fine Needle Biopsy
Kidney
Lymphoma
Immunophenotyping
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Renal Cell Carcinoma
Non-Hodgkin's Lymphoma
Population
Neoplasms
Flow Cytometry
Tomography
Lymphocytes
Neoplasm Metastasis
Carcinoma
Biopsy
Light
Recurrence
Infection

Keywords

  • Fine-needle aspiration
  • Lymphoproliferative disorder
  • Renal lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Lymphoproliferative disorders of the kidney on fine-needle aspiration : Cytomorphology and radiographic correlates in 33 cases. / Subhawong, Andrea P.; Subhawong, Ty; Vandenbussche, Christopher J.; Siddiqui, Momin T.; Ali, Syed Z.

In: Acta Cytologica, Vol. 57, No. 1, 01.01.2013, p. 19-25.

Research output: Contribution to journalArticle

Subhawong, Andrea P. ; Subhawong, Ty ; Vandenbussche, Christopher J. ; Siddiqui, Momin T. ; Ali, Syed Z. / Lymphoproliferative disorders of the kidney on fine-needle aspiration : Cytomorphology and radiographic correlates in 33 cases. In: Acta Cytologica. 2013 ; Vol. 57, No. 1. pp. 19-25.
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