LymphomiRs: MicroRNAs with regulatory roles in lymphomas

Goldi A. Kozloski, Izidore Lossos

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose of review This review provides current knowledge on the role of microRNAs (miRNAs) in lymphoma with an emphasis on mature B-cell lymphoma. Recent findings Although miRNAs were previously used to stratify lymphoma classification, prognosis, or treatment response, recent publications portray this class of small noncoding RNAs as critical players in the lymphomagenesis process. Although functional studies provide ample evidence for their role as lymphoma drivers or suppressors, genetic studies providing the underlying mechanisms for these phenotypes are still lacking. As more whole-genome sequencing of lymphoma cases become available, this gap may be soon filled. Summary Current findings highlight the potential role of miRNAs molecules as important factors in lymphomagenesis.

Original languageEnglish (US)
Pages (from-to)362-368
Number of pages7
JournalCurrent Opinion in Hematology
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2015

Keywords

  • Activation-induced deaminase
  • Germinal center
  • Lymphoma
  • MicroRNAs
  • MIR-155

ASJC Scopus subject areas

  • Hematology

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