Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years

A. S. Fauci, B. F. Haynes, J. Costa, P. Katz, S. M. Wolff

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90%. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 ± 0.6 years (mean ± S.E.M.). Six of the seven with disease in remission have received no therapy for 28.3 ± 5.7 months. Malignant lymphoma developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also prevent the development of a lymphoid neoplasm.

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalNew England Journal of Medicine
Volume306
Issue number2
StatePublished - Sep 20 1982
Externally publishedYes

Fingerprint

Lymphomatoid Granulomatosis
Prednisone
Cyclophosphamide
Lymphoma
Therapeutics
Body Weight
Mortality
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fauci, A. S., Haynes, B. F., Costa, J., Katz, P., & Wolff, S. M. (1982). Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. New England Journal of Medicine, 306(2), 68-74.

Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. / Fauci, A. S.; Haynes, B. F.; Costa, J.; Katz, P.; Wolff, S. M.

In: New England Journal of Medicine, Vol. 306, No. 2, 20.09.1982, p. 68-74.

Research output: Contribution to journalArticle

Fauci, AS, Haynes, BF, Costa, J, Katz, P & Wolff, SM 1982, 'Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years', New England Journal of Medicine, vol. 306, no. 2, pp. 68-74.
Fauci, A. S. ; Haynes, B. F. ; Costa, J. ; Katz, P. ; Wolff, S. M. / Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. In: New England Journal of Medicine. 1982 ; Vol. 306, No. 2. pp. 68-74.
@article{1dd1164f23dd436caac5a1b780ea3bcb,
title = "Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years",
abstract = "Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90{\%}. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 ± 0.6 years (mean ± S.E.M.). Six of the seven with disease in remission have received no therapy for 28.3 ± 5.7 months. Malignant lymphoma developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also prevent the development of a lymphoid neoplasm.",
author = "Fauci, {A. S.} and Haynes, {B. F.} and J. Costa and P. Katz and Wolff, {S. M.}",
year = "1982",
month = "9",
day = "20",
language = "English",
volume = "306",
pages = "68--74",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "2",

}

TY - JOUR

T1 - Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years

AU - Fauci, A. S.

AU - Haynes, B. F.

AU - Costa, J.

AU - Katz, P.

AU - Wolff, S. M.

PY - 1982/9/20

Y1 - 1982/9/20

N2 - Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90%. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 ± 0.6 years (mean ± S.E.M.). Six of the seven with disease in remission have received no therapy for 28.3 ± 5.7 months. Malignant lymphoma developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also prevent the development of a lymphoid neoplasm.

AB - Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol of cyclophosphamide (2 mg per kilogram of body weight per day) and prednisone (1 mg per kilogram on alternate days). Previous reports had indicated that mortality from lymphomatoid granulomatosis was as high as 90%. Of the 13 patients who received the cyclophosphamide and prednisone protocol, seven had complete remissions lasting for 5.2 ± 0.6 years (mean ± S.E.M.). Six of the seven with disease in remission have received no therapy for 28.3 ± 5.7 months. Malignant lymphoma developed in seven of the eight who died, and only two of the eight had therapy for an adequate period. Since virtually all patients who did not have complete remission went on to have malignant lymphoma, early recognition and prompt treatment during the lymphomatoid-granulomatosis phase of disease may not only lead to complete remissions but also prevent the development of a lymphoid neoplasm.

UR - http://www.scopus.com/inward/record.url?scp=0019956263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019956263&partnerID=8YFLogxK

M3 - Article

C2 - 7053488

AN - SCOPUS:0019956263

VL - 306

SP - 68

EP - 74

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 2

ER -