Lymphomas involving the pleura: A clinicopathologic study of 34 cases diagnosed by pleural biopsy

Francisco Vega, Anthony Padula, Jose R. Valbuena, Mirela Stancu, Dan Jones, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

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Abstract

Context. - Pleural involvement by lymphoma is relatively common. However, there are very few clinicopathologic studies reported in the literature of lymphomas involving the pleura. Objective. - To characterize the clinicopathologic features of lymphomas involving the pleura. Design. - We reviewed the clinicopathologic features of 34 patients with lymphoma involving the pleura proven by biopsy and classified these neoplasms using the World Health Organization classification. Results. - There were 22 men and 12 women, with an average age of 62 years (range, 22-82 years). Nine (26.5%) patients had pleural involvement as the only site of disease, 22 (64.7%) had other sites of involvement, and 3 (8.8%) had inadequate staging data. Eighteen (56.2%) of 32 patients with adequate clinical data had a history of lymphoma (including 3 patients with pleural involvement as the only disease site). In 29 (85.3%) cases, a specific diagnosis according to the World Health Organization classification could be made: 17 (58.6%) diffuse large B-cell lymphoma, 5 (17.2%) follicular lymphoma (including a case with areas of diffuse large B-cell lymphoma), 2 (6.9%) small lymphocytic lymphomas/chronic lymphocytic leukemia, 2 (6.9%) precursor T-cell lymphoblastic lymphoma/leukemia, 1 (3.4%) mantle cell lymphoma, 1 (3.4%) posttransplant lymphoproliferative disorder, and 1 (3.4%) classical Hodgkin lymphoma. The other 5 cases were B-cell lymphomas that could not be further classified. Cytologic examination of pleural fluid was performed in 15 cases and was positive for lymphoma in 8 (53.3%) cases. Conclusions. - Most patients with lymphoma involving the pleura have simultaneous evidence of systemic involvement. The most frequent type is diffuse large B-cell lymphoma, followed by follicular lymphoma. Cytologic examination can have negative results in patients with pleural involvement by lymphoma.

Original languageEnglish
Pages (from-to)1497-1502
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number10
StatePublished - Oct 1 2006
Externally publishedYes

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Pleura
Lymphoma
Biopsy
Lymphoma, Large B-Cell, Diffuse
Follicular Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mantle-Cell Lymphoma
Lymphoproliferative Disorders
B-Cell Lymphoma
Hodgkin Disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Vega, F., Padula, A., Valbuena, J. R., Stancu, M., Jones, D., & Medeiros, L. J. (2006). Lymphomas involving the pleura: A clinicopathologic study of 34 cases diagnosed by pleural biopsy. Archives of Pathology and Laboratory Medicine, 130(10), 1497-1502.

Lymphomas involving the pleura : A clinicopathologic study of 34 cases diagnosed by pleural biopsy. / Vega, Francisco; Padula, Anthony; Valbuena, Jose R.; Stancu, Mirela; Jones, Dan; Medeiros, L. Jeffrey.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 10, 01.10.2006, p. 1497-1502.

Research output: Contribution to journalArticle

Vega, F, Padula, A, Valbuena, JR, Stancu, M, Jones, D & Medeiros, LJ 2006, 'Lymphomas involving the pleura: A clinicopathologic study of 34 cases diagnosed by pleural biopsy', Archives of Pathology and Laboratory Medicine, vol. 130, no. 10, pp. 1497-1502.
Vega, Francisco ; Padula, Anthony ; Valbuena, Jose R. ; Stancu, Mirela ; Jones, Dan ; Medeiros, L. Jeffrey. / Lymphomas involving the pleura : A clinicopathologic study of 34 cases diagnosed by pleural biopsy. In: Archives of Pathology and Laboratory Medicine. 2006 ; Vol. 130, No. 10. pp. 1497-1502.
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abstract = "Context. - Pleural involvement by lymphoma is relatively common. However, there are very few clinicopathologic studies reported in the literature of lymphomas involving the pleura. Objective. - To characterize the clinicopathologic features of lymphomas involving the pleura. Design. - We reviewed the clinicopathologic features of 34 patients with lymphoma involving the pleura proven by biopsy and classified these neoplasms using the World Health Organization classification. Results. - There were 22 men and 12 women, with an average age of 62 years (range, 22-82 years). Nine (26.5{\%}) patients had pleural involvement as the only site of disease, 22 (64.7{\%}) had other sites of involvement, and 3 (8.8{\%}) had inadequate staging data. Eighteen (56.2{\%}) of 32 patients with adequate clinical data had a history of lymphoma (including 3 patients with pleural involvement as the only disease site). In 29 (85.3{\%}) cases, a specific diagnosis according to the World Health Organization classification could be made: 17 (58.6{\%}) diffuse large B-cell lymphoma, 5 (17.2{\%}) follicular lymphoma (including a case with areas of diffuse large B-cell lymphoma), 2 (6.9{\%}) small lymphocytic lymphomas/chronic lymphocytic leukemia, 2 (6.9{\%}) precursor T-cell lymphoblastic lymphoma/leukemia, 1 (3.4{\%}) mantle cell lymphoma, 1 (3.4{\%}) posttransplant lymphoproliferative disorder, and 1 (3.4{\%}) classical Hodgkin lymphoma. The other 5 cases were B-cell lymphomas that could not be further classified. Cytologic examination of pleural fluid was performed in 15 cases and was positive for lymphoma in 8 (53.3{\%}) cases. Conclusions. - Most patients with lymphoma involving the pleura have simultaneous evidence of systemic involvement. The most frequent type is diffuse large B-cell lymphoma, followed by follicular lymphoma. Cytologic examination can have negative results in patients with pleural involvement by lymphoma.",
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