Lymphoma in macaques: Association with virus of human T lymphotrophic family

T. Homma, P. J. Kanki, N. W. King, R. D. Hunt, M. J. O'Connell, N. L. Letvin, M. D. Daniel, R. C. Desrosiers, C. S. Yang, M. Essex

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Human T-cell leukemia virus has been linked with adult T-cell leukemia-lymphoma (ATLL), a tumor of mature T cells that occurs at elevated rates in southwestern Japan and in the Caribbean Basin. Human T-cell leukemia virus (HTLV) or a closely related virus, has also been found in varying proportions of healthy individuals of several species of Old World monkeys. In the present study, conducted with macaques from Taiwan and the New England Regional Primate Research Center, antibodies to membrane antigens of HTLV-infected cells (HTLV-MA) were found in 11 of 13 macaques with malignant lymphoma or lymphoproliferative disease but in only 7 of 95 of healthy macaques. This indicates that antibodies to HTLV are significantly associated with the development of naturally occurring lymphoid neoplasms in at least some species of nonhuman primates.

Original languageEnglish (US)
Pages (from-to)716-718
Number of pages3
JournalScience
Volume225
Issue number4663
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Lymphoma in macaques: Association with virus of human T lymphotrophic family'. Together they form a unique fingerprint.

  • Cite this

    Homma, T., Kanki, P. J., King, N. W., Hunt, R. D., O'Connell, M. J., Letvin, N. L., Daniel, M. D., Desrosiers, R. C., Yang, C. S., & Essex, M. (1984). Lymphoma in macaques: Association with virus of human T lymphotrophic family. Science, 225(4663), 716-718. https://doi.org/10.1126/science.6087453