Lymphocyte immunophenotypes among anti-HTLV-I/-II-positive blood donors and recipients

Transfusion Safety Study Group

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HTLV) at that time. They and their recipients have been traced for additional HTLV studies. Immunophenotypic analyses of peripheral blood lymphocytes from nine anti-HTLV-positive recipients, assumed to be infected during or since late 1984, showed no significant changes from healthy controls. Evaluation of the immunophenotypes of the 48 donors, however, showed significant elevations in the absolute counts of the T-cell (CD2) and natural killer (CD56) populations, the T helper/inducer and suppressor/inducer subsets (CD4+CD29+ and CD4+CD45RA+), and changes in T-cell activation markers. Long-term bu not recent HTLV infection appears to alter the T-cell immunophenotypic pattern. Both infection with HTLV and human immunodeficiency virus type 1 are associated with a decreased CD2+CD26+ count.

Original languageEnglish (US)
Pages (from-to)628-632
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume4
Issue number6
StatePublished - Jun 1991

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Keywords

  • Blood donors
  • Blood transfusion
  • Human T-cell lymphotrophic virus infection
  • T-lymphocytes

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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