Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

Young Kwon Hong, Kimberly Foreman, Jay W. Shin, Satoshi Hirakawa, Christine Curry, David R. Sage, Towia Libermann, Bruce J. Dezube, Joyce D. Fingeroth, Michael Detmar

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

Original languageEnglish (US)
Pages (from-to)683-685
Number of pages3
JournalNature Genetics
Volume36
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

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Human Herpesvirus 8
Vascular Endothelium
Kaposi's Sarcoma
Lymphatic Endothelium
Genes
Blood Vessels
Neoplasms
Down-Regulation
Endothelial Cells
Infection

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Hong, Y. K., Foreman, K., Shin, J. W., Hirakawa, S., Curry, C., Sage, D. R., ... Detmar, M. (2004). Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics, 36(7), 683-685. https://doi.org/10.1038/ng1383

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. / Hong, Young Kwon; Foreman, Kimberly; Shin, Jay W.; Hirakawa, Satoshi; Curry, Christine; Sage, David R.; Libermann, Towia; Dezube, Bruce J.; Fingeroth, Joyce D.; Detmar, Michael.

In: Nature Genetics, Vol. 36, No. 7, 07.2004, p. 683-685.

Research output: Contribution to journalArticle

Hong, YK, Foreman, K, Shin, JW, Hirakawa, S, Curry, C, Sage, DR, Libermann, T, Dezube, BJ, Fingeroth, JD & Detmar, M 2004, 'Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus', Nature Genetics, vol. 36, no. 7, pp. 683-685. https://doi.org/10.1038/ng1383
Hong YK, Foreman K, Shin JW, Hirakawa S, Curry C, Sage DR et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics. 2004 Jul;36(7):683-685. https://doi.org/10.1038/ng1383
Hong, Young Kwon ; Foreman, Kimberly ; Shin, Jay W. ; Hirakawa, Satoshi ; Curry, Christine ; Sage, David R. ; Libermann, Towia ; Dezube, Bruce J. ; Fingeroth, Joyce D. ; Detmar, Michael. / Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. In: Nature Genetics. 2004 ; Vol. 36, No. 7. pp. 683-685.
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