Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

Young Kwon Hong, Kimberly Foreman, Jay W. Shin, Satoshi Hirakawa, Christine L. Curry, David R. Sage, Towia Libermann, Bruce J. Dezube, Joyce D. Fingeroth, Michael Detmar

Research output: Contribution to journalArticlepeer-review

291 Scopus citations

Abstract

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

Original languageEnglish (US)
Pages (from-to)683-685
Number of pages3
JournalNature genetics
Volume36
Issue number7
DOIs
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Genetics

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