Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

Young Kwon Hong, Kimberly Foreman, Jay W. Shin, Satoshi Hirakawa, Christine L. Curry, David R. Sage, Towia Libermann, Bruce J. Dezube, Joyce D. Fingeroth, Michael Detmar

Research output: Contribution to journalArticle

290 Scopus citations

Abstract

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

Original languageEnglish (US)
Pages (from-to)683-685
Number of pages3
JournalNature genetics
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus'. Together they form a unique fingerprint.

  • Cite this

    Hong, Y. K., Foreman, K., Shin, J. W., Hirakawa, S., Curry, C. L., Sage, D. R., Libermann, T., Dezube, B. J., Fingeroth, J. D., & Detmar, M. (2004). Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature genetics, 36(7), 683-685. https://doi.org/10.1038/ng1383