Lymphatic drainage patterns in oral squamous cell carcinoma: Findings of the ACOSOG Z0360 (Alliance) study

Roger W. Farmer, Linda McCall, Francisco Civantos, Jeffrey N. Myers, Wendell G. Yarbrough, Barbara Murphy, Miriam O'Leary, Robert Zitsch, Barry A. Siegel

Research output: Contribution to journalArticle

12 Scopus citations


Objective. The purpose of our study was to correlate sentinel lymph nodes (SLN) found on planar lymphoscintigraphy (LS) to SLN found with gamma probe-directed sentinel lymph node biopsy (SLNB) for T1/T2 N0 oral cavity cancer. Study Design. Prospective cooperative group trial. Setting. Academic medical centers. Subjects and Methods. One hundred forty adults with untreated T1/T2 N0 squamous cell carcinoma (SCC) of the oral cavity underwent planar LS, resection, SLNB, and neck dissection. Location of SLN by planar LS and SLNB and of metastases were compared to each other and historical data of regional metastases. Results. SLNs located by planar LS and SLNB were predominantly in levels I through IV. There was heterogeneity in the number of SLNs found at planar LS and at SLNB, which was significantly different in levels II and III (P

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number4
StatePublished - Apr 7 2015


  • lymphoscintigraphy
  • oral squamous cell carcinoma
  • sentinel lymph node

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

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