Lymph Node Sampling and Survival in Child and Adolescent Extremity Soft Tissue Sarcoma

Ann Christina Brady, Omar Picado, Jun Tashiro, Juan E. Sola, Eduardo A. Perez

Research output: Contribution to journalArticle

Abstract

Background: The significance of lymph node sampling (LNS) on disease-specific survival (DSS) of extremity soft tissue sarcomas (STS) is unknown. We investigated the effect of LNS on DSS in child and adolescent extremity STS. Materials and methods: The Surveillance, Epidemiology, and End Results registry was queried for patients aged <20 y with extremity STS who underwent surgery. Patient demographics were collected and analyzed. Results: A total of 1550 patients were included, with findings of 10-y DSS of 74% for all extremity STS and 49% for rhabdoymyosarcoma (RMS) (P < 0.005). LNS was associated with worse DSS in patients with extremity nonrhabdomyosacrcoma soft tissue sarcomas (79% versus 84%, P = 0.036). Conversely, LNS was associated with an improved DSS in patients with extremity RMS (64% versus 49%, P = 0.005). Conclusions: LNS is positively associated with an improved DSS in child and adolescent extremity RMS. Multivariate analysis found no correlation between DSS and LNS in child and adolescent extremity nonrhabdomyosarcoma soft tissue sarcomas.

Original languageEnglish (US)
Pages (from-to)205-214
Number of pages10
JournalJournal of Surgical Research
Volume241
DOIs
StatePublished - Sep 1 2019

Keywords

  • Lymph node sampling
  • Nonrhabdomyosarcoma
  • Pediatric extremity soft tissue sarcoma
  • Rhabdomyosarcoma
  • SEER

ASJC Scopus subject areas

  • Surgery

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