Luxury perfusion phenomenon in acute herpes simplex virus encephalitis

Makoto Tanaka, Makoto Uesugi, Yukifusa Igeta, Susumu Kondo, Xiaoyan Sun, Shunsaku Hirai

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


In a patient with acute herpes simplex virus (HSV) encephalitis, positron emission tomography (PET) demonstrated increased cerebral blood flow in the affected temporal lobe accompanied by reduction in the cerebral oxygen extraction fraction and the cerebral metabolic rate of oxygen, i.e., luxury perfusion. Follow-up PET studies showed reduction in cerebral perfusion until it was more closely coupled with oxygen metabolism after the resolution of the acute inflammation. These findings support previous single photon emission computed tomographic data and provide a pathophysiological background for the occurrence of hyperperfusion in HSV encephalitis. This is an interesting example of the luxury perfusion phenomenon occurring in a disease other than cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)43-45
Number of pages3
JournalAnnals of Nuclear Medicine
Issue number1
StatePublished - Mar 1 1995
Externally publishedYes


  • herpes simplex virus encephalitis
  • luxury perfusion phenomenon
  • positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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