Luteinizing hormone releasing hormone in the treatment of anovulatory infertility

P. R. Casas, A. R. Badano, N. Aparicio, L. J. Lencioni, R. R. Berli, H. Badano, C. Biccoca, Andrew V Schally

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fifteen infertile, anovulatory women, ages 20 to 37, were treated with synthetic luteinizing hormone releasing hormone (LH RH) to stimulate follicular maturation and/or ovulation. Thirteen of the patients had been treated unsuccessfully with other therapeutic regimens. To obtain follicular maturation, LH RH was given intramuscularly in daily doses of 25 μg for 7 days and 50 μg for the next 7 days, or 100 μg for 3 days and 150 μg for the next 3 days. Both regimens were begun on the 4th day of a spontaneous or induced cycle. Follicular maturation (evaluated by the cervical mucus scale) occurred in three of seven cycles treated with the first regimen and three of five treated with the second regimen. To induce ovulation, LH RH was given in intravenous infusion (50 to 500 μg), intramuscularly (100 μg), or in a combination of both methods. The drug was administered after follicular maturation with LH RH, clomiphene citrate, or human menopausal gonadotropin had been achieved; it was also given during four cycles in which spontaneous follicular maturation had occurred. Ovulation occurred in 10 of 25 treated cycles. Five pregnancies resulted, three in the first post treatment cycle.

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalFertility and Sterility
Volume26
Issue number6
StatePublished - Dec 1 1975
Externally publishedYes

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Gonadotropin-Releasing Hormone
Infertility
Ovulation
Menotropins
Cervix Mucus
Clomiphene
Therapeutics
Intravenous Infusions
Pregnancy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Casas, P. R., Badano, A. R., Aparicio, N., Lencioni, L. J., Berli, R. R., Badano, H., ... Schally, A. V. (1975). Luteinizing hormone releasing hormone in the treatment of anovulatory infertility. Fertility and Sterility, 26(6), 549-553.

Luteinizing hormone releasing hormone in the treatment of anovulatory infertility. / Casas, P. R.; Badano, A. R.; Aparicio, N.; Lencioni, L. J.; Berli, R. R.; Badano, H.; Biccoca, C.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 26, No. 6, 01.12.1975, p. 549-553.

Research output: Contribution to journalArticle

Casas, PR, Badano, AR, Aparicio, N, Lencioni, LJ, Berli, RR, Badano, H, Biccoca, C & Schally, AV 1975, 'Luteinizing hormone releasing hormone in the treatment of anovulatory infertility', Fertility and Sterility, vol. 26, no. 6, pp. 549-553.
Casas PR, Badano AR, Aparicio N, Lencioni LJ, Berli RR, Badano H et al. Luteinizing hormone releasing hormone in the treatment of anovulatory infertility. Fertility and Sterility. 1975 Dec 1;26(6):549-553.
Casas, P. R. ; Badano, A. R. ; Aparicio, N. ; Lencioni, L. J. ; Berli, R. R. ; Badano, H. ; Biccoca, C. ; Schally, Andrew V. / Luteinizing hormone releasing hormone in the treatment of anovulatory infertility. In: Fertility and Sterility. 1975 ; Vol. 26, No. 6. pp. 549-553.
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