TY - JOUR
T1 - Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure
AU - Okada, Y.
AU - Kitamura, K.
AU - Baba, Y.
AU - Arimura, A.
AU - Schally, A. V.
PY - 1973/8/21
Y1 - 1973/8/21
N2 - Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.
AB - Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.
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U2 - 10.1016/0006-291X(73)90589-5
DO - 10.1016/0006-291X(73)90589-5
M3 - Article
C2 - 4584019
AN - SCOPUS:0015798031
VL - 53
SP - 1180
EP - 1186
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -