Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure

Y. Okada, K. Kitamura, Y. Baba, A. Arimura, A. V. Schally

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.

Original languageEnglish (US)
Pages (from-to)1180-1186
Number of pages7
JournalBiochemical and biophysical research communications
Volume53
Issue number4
DOIs
StatePublished - Aug 21 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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