Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|State||Published - Aug 21 1973|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology