Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure

Y. Okada; K. Kitamura; Y. Baba; A. Arimura; A. V. Schally

doi:10.1016/0006-291X(73)90589-5

Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure

Y. Okada, K. Kitamura, Y. Baba, A. Arimura, A. V. Schally

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly¹-LH-RH, formyl Gly¹-LH-RH, acetyl Gly¹-LH-RH, propionyl Gly¹-LH-RH, palmitoyl Gly¹-LH-RH and acetyl Ala¹-LH-RH were synthesized. The Gly¹ analog was inactive, whereas acyl Gly¹ analogs except palmitoyl Gly¹ analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.

Original language	English (US)
Pages (from-to)	1180-1186
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(73)90589-5
State	Published - Aug 21 1973
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure",

abstract = "Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.",

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T1 - Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure

AU - Okada, Y.

AU - Kitamura, K.

AU - Baba, Y.

AU - Arimura, A.

AU - Schally, A. V.

PY - 1973/8/21

Y1 - 1973/8/21

N2 - Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.

AB - Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly1-LH-RH, formyl Gly1-LH-RH, acetyl Gly1-LH-RH, propionyl Gly1-LH-RH, palmitoyl Gly1-LH-RH and acetyl Ala1-LH-RH were synthesized. The Gly1 analog was inactive, whereas acyl Gly1 analogs except palmitoyl Gly1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.

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