Lung radiofrequency ablation: In vivo experimental study with low-perfusion-rate multitined electrodes

Laura Crocetti, Riccardo Lencioni, Elena Bozzi, Alberto Sbrana, Carlo Bartolozzi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study was to investigate the feasibility and safety of lung radiofrequency (RF) ablation by using low-perfusion-rate, expandable, multitined electrodes in an in vivo animal model. Ten New Zealand White rabbits underwent RF ablation using low-perfusion-rate, expandable, multitined electrodes (Starburst Talon; RITA Medical Systems, Mountain View, CA) and a 200-W RF generator. The electrode was positioned under fluoroscopy guidance and a single percutaneous RF ablation was performed. Saline perfusate was doped with nonionic iodinated contrast agent to render it visible on computed tomography (CT). The pump infused the saline doped with contrast agent into the lateral tines at a rate of 0.1ml/min. The planned ablation was of 3 min, with the hooks deployed to 2 cm at a target temperature of 105°C. An immediate posttreatment CT scan documented the distribution of the doped saline and the presence of immediate complications. The animals were monitored for delayed complications and sacrificed within 72 h (n = 4), 2 weeks (n = 3), or 4 weeks (n = 3). Assessment of ablation zone and adjacent structures was done at autopsy. Major complications consisted of pneumothorax requiring drainage (n = 2) and skin burn (n = 1). Immediately after the procedure the area of ablation was depicted at CT as a round, well-demarcated area, homogeneously opacified by iodinated contrast medium (mean size, 2.3 ± 0.8 cm). The presence of a sharply demarcated area of coagulation necrosis (mean size, 2.1 ± 0.4 cm) without severe damage to adjacent structures was confirmed at autopsy. In one case, euthanized at 4 weeks, in whom pneumothorax and pleural effusion were depicted, pleural fibrinous adhesions were demonstrated at autopsy. In conclusion, lung RF ablation performed in an in vivo animal model using low-perfusion-rate, expandable, multitined electrodes is feasible and safe. No severe damage to adjacent structures was demonstrated.

Original languageEnglish (US)
Pages (from-to)610-618
Number of pages9
JournalCardioVascular and Interventional Radiology
Volume31
Issue number3
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Electrodes
Perfusion
Contrast Media
Autopsy
Lung
Tomography
Pneumothorax
Animal Models
Fluoroscopy
Pleural Effusion
Drainage
Necrosis
Rabbits
Safety
Skin
Temperature

Keywords

  • Lung neoplasm
  • Perfused electrodes
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Lung radiofrequency ablation : In vivo experimental study with low-perfusion-rate multitined electrodes. / Crocetti, Laura; Lencioni, Riccardo; Bozzi, Elena; Sbrana, Alberto; Bartolozzi, Carlo.

In: CardioVascular and Interventional Radiology, Vol. 31, No. 3, 05.2008, p. 610-618.

Research output: Contribution to journalArticle

Crocetti, Laura ; Lencioni, Riccardo ; Bozzi, Elena ; Sbrana, Alberto ; Bartolozzi, Carlo. / Lung radiofrequency ablation : In vivo experimental study with low-perfusion-rate multitined electrodes. In: CardioVascular and Interventional Radiology. 2008 ; Vol. 31, No. 3. pp. 610-618.
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