Lung perfusion during cardiac surgery with cardiopulmonary bypass: Is it necessary?

Edmo Atique Gabriel, Rafael Fagionato Locali, Priscila Katsumi Matsuoka, Ludmila Santiago Almeida, Ismael Guerreiro Silva, Vera Lúcia Capelozzi, Tomas Antonio Salerno, Enio Buffolo

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Thirty-two pigs were randomized into group I (aortic cross clamping, antegrade cardioplegia, moderate hypothermia) and group II (normothermia, beating empty heart). Groups were subdivided into subgroups A, B and C, receiving no lung perfusion, perfusion with arterial blood and perfusion with venous blood. Swan-Ganz catheter was used to take mean pulmonary artery pressure which would be used as lung perfusion pressure. Cardiopulmonary bypass (CPB) was established through cannulating aorta and double venae cavae, mechanical ventilation was interrupted and lung perfusion was carried out for 30 min. Blood samples and pulmonary specimens were withdrawn pre- and postoperatively for gasometrical, histological and genic analyses. Postoperative comparison revealed that pulmonary vascular resistance was lower in IC than IA (P=0.01) and it was lower in IIC than IIA (P=0.005). Subgroup IIB had increasing venous oxygen tension (P=0.01) as well as arterial and venous oxygen saturation (P=0.01) compared to IIA. Arterial oxygen saturation was decreased in IIC vs. IIA (P=0.006). Histological differences were observed between subgroups A and B as well as A and C (P=0.003). Lung perfusion during CPB may improve pulmonary hemodynamic performance, optimize gas exchange and maintain cellular integrity.

Original languageEnglish (US)
Pages (from-to)1089-1095
Number of pages7
JournalInteractive cardiovascular and thoracic surgery
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Cardiopulmonary bypass
  • Lung
  • Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

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  • Cite this

    Gabriel, E. A., Locali, R. F., Matsuoka, P. K., Almeida, L. S., Silva, I. G., Capelozzi, V. L., Salerno, T. A., & Buffolo, E. (2008). Lung perfusion during cardiac surgery with cardiopulmonary bypass: Is it necessary? Interactive cardiovascular and thoracic surgery, 7(6), 1089-1095. https://doi.org/10.1510/icvts.2008.184275