TY - JOUR
T1 - Lung mechanics in congenital heart disease with increased and decreased pulmonary blood flow
AU - Bancalari, E.
AU - Jesse, M. J.
AU - Gelband, H.
AU - Garcia, O.
N1 - Funding Information:
From the Divisions of Newborn Medicine and Pediatric Cardiology, Department of Pediatrics, University of Miami School of Medicine. Supported in part by the National Foundation, Research and Service Grant C-75, and the Joyce Biel Adler Neonatal'Research Grant. *Reprint address: University of Miami School of Medicine, PO Box 520875, Biscayne Annex, Miami. FL 33152.
PY - 1977/2
Y1 - 1977/2
N2 - Respiratory rate, tidal volume, dynamic lung compliance, functional residual capacity, and pulmonary resistance were measured within 24 hours of cardiac catheterization in 25 infants, 12 of whom had increased pulmonary blood flow and 13 of whom had decreased PBF. There were no differences in the two groups of patients with respect to Vτ and FRC. Respiratory rate and pulmonary resistance were higher in infants with increased PBF. Lung compliance was significantly lower in infants with increased PBF (4.9 ml/cm H2O) than in those with decreased PBF (8.9 ml/cm H2O) (P<0.01). The decrease in CL in infants with increased PBF significantly correlated with mean pulmonary artery pressure (r=0.798). No correlation was found between CL and left atrial pressure or magnitude of the left-to-right shunt. Compliance was normal in patients with increased PBF and normal PAP, suggesting that PAP and not PBF is the primary factor that affects CL in patients with intracardiac left-to-right shunts.
AB - Respiratory rate, tidal volume, dynamic lung compliance, functional residual capacity, and pulmonary resistance were measured within 24 hours of cardiac catheterization in 25 infants, 12 of whom had increased pulmonary blood flow and 13 of whom had decreased PBF. There were no differences in the two groups of patients with respect to Vτ and FRC. Respiratory rate and pulmonary resistance were higher in infants with increased PBF. Lung compliance was significantly lower in infants with increased PBF (4.9 ml/cm H2O) than in those with decreased PBF (8.9 ml/cm H2O) (P<0.01). The decrease in CL in infants with increased PBF significantly correlated with mean pulmonary artery pressure (r=0.798). No correlation was found between CL and left atrial pressure or magnitude of the left-to-right shunt. Compliance was normal in patients with increased PBF and normal PAP, suggesting that PAP and not PBF is the primary factor that affects CL in patients with intracardiac left-to-right shunts.
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U2 - 10.1016/S0022-3476(77)80628-8
DO - 10.1016/S0022-3476(77)80628-8
M3 - Article
C2 - 830909
AN - SCOPUS:0017594194
VL - 90
SP - 192
EP - 195
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 2
ER -