Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher, Sharon Elliot, Gustavo A. Rubio, Marilyn K Glassberg Csete

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

Original languageEnglish (US)
Pages (from-to)473-490
Number of pages18
JournalClinics in Geriatric Medicine
Volume33
Issue number4
DOIs
StatePublished - Nov 1 2017

Keywords

  • Aging
  • Cellular senescence
  • COPD
  • Idiopathic pulmonary fibrosis
  • Stem cells

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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