Abstract
Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 473-490 |
| Number of pages | 18 |
| Journal | Clinics in Geriatric Medicine |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 1 2017 |
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Keywords
- Aging
- Cellular senescence
- COPD
- Idiopathic pulmonary fibrosis
- Stem cells
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Lung Diseases of the Elderly : Cellular Mechanisms. / Ascher, Kori; Elliot, Sharon; Rubio, Gustavo A.; Glassberg Csete, Marilyn K.
In: Clinics in Geriatric Medicine, Vol. 33, No. 4, 01.11.2017, p. 473-490.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Lung Diseases of the Elderly
T2 - Cellular Mechanisms
AU - Ascher, Kori
AU - Elliot, Sharon
AU - Rubio, Gustavo A.
AU - Glassberg Csete, Marilyn K
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.
AB - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.
KW - Aging
KW - Cellular senescence
KW - COPD
KW - Idiopathic pulmonary fibrosis
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85027568201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027568201&partnerID=8YFLogxK
U2 - 10.1016/j.cger.2017.07.001
DO - 10.1016/j.cger.2017.07.001
M3 - Review article
C2 - 28991645
AN - SCOPUS:85027568201
VL - 33
SP - 473
EP - 490
JO - Clinics in Geriatric Medicine
JF - Clinics in Geriatric Medicine
SN - 0749-0690
IS - 4
ER -