Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher, Sharon Elliot, Gustavo A. Rubio, Marilyn K Glassberg Csete

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

Original languageEnglish (US)
Pages (from-to)473-490
Number of pages18
JournalClinics in Geriatric Medicine
Volume33
Issue number4
DOIs
StatePublished - Nov 1 2017

Fingerprint

Lung Diseases
Lung
Idiopathic Pulmonary Fibrosis
Cell Aging
Telomere
Environmental Exposure
Chronic Obstructive Pulmonary Disease
DNA Damage
Oxidative Stress
Chronic Disease
Stem Cells
Apoptosis
Incidence
Population

Keywords

  • Aging
  • Cellular senescence
  • COPD
  • Idiopathic pulmonary fibrosis
  • Stem cells

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Lung Diseases of the Elderly : Cellular Mechanisms. / Ascher, Kori; Elliot, Sharon; Rubio, Gustavo A.; Glassberg Csete, Marilyn K.

In: Clinics in Geriatric Medicine, Vol. 33, No. 4, 01.11.2017, p. 473-490.

Research output: Contribution to journalReview article

@article{1afc32ac9da547578f4d5ab47917f388,
title = "Lung Diseases of the Elderly: Cellular Mechanisms",
abstract = "Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.",
keywords = "Aging, Cellular senescence, COPD, Idiopathic pulmonary fibrosis, Stem cells",
author = "Kori Ascher and Sharon Elliot and Rubio, {Gustavo A.} and {Glassberg Csete}, {Marilyn K}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.cger.2017.07.001",
language = "English (US)",
volume = "33",
pages = "473--490",
journal = "Clinics in Geriatric Medicine",
issn = "0749-0690",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Lung Diseases of the Elderly

T2 - Cellular Mechanisms

AU - Ascher, Kori

AU - Elliot, Sharon

AU - Rubio, Gustavo A.

AU - Glassberg Csete, Marilyn K

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

AB - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

KW - Aging

KW - Cellular senescence

KW - COPD

KW - Idiopathic pulmonary fibrosis

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85027568201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027568201&partnerID=8YFLogxK

U2 - 10.1016/j.cger.2017.07.001

DO - 10.1016/j.cger.2017.07.001

M3 - Review article

C2 - 28991645

AN - SCOPUS:85027568201

VL - 33

SP - 473

EP - 490

JO - Clinics in Geriatric Medicine

JF - Clinics in Geriatric Medicine

SN - 0749-0690

IS - 4

ER -