Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher; Sharon Elliot; Gustavo A. Rubio; Marilyn K Glassberg Csete

doi:10.1016/j.cger.2017.07.001

Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher, Sharon Elliot, Gustavo A. Rubio, Marilyn K Glassberg Csete

Research output: Contribution to journal › Review article

8 Scopus citations

Abstract

Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

Original language	English (US)
Pages (from-to)	473-490
Number of pages	18
Journal	Clinics in Geriatric Medicine
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.cger.2017.07.001
State	Published - Nov 1 2017

Keywords

Aging
Cellular senescence
COPD
Idiopathic pulmonary fibrosis
Stem cells

ASJC Scopus subject areas

Geriatrics and Gerontology

Access to Document

10.1016/j.cger.2017.07.001

Fingerprint Dive into the research topics of 'Lung Diseases of the Elderly: Cellular Mechanisms'. Together they form a unique fingerprint.

Cite this

Ascher, K., Elliot, S., Rubio, G. A., & Glassberg Csete, M. K. (2017). Lung Diseases of the Elderly: Cellular Mechanisms. Clinics in Geriatric Medicine, 33(4), 473-490. https://doi.org/10.1016/j.cger.2017.07.001

@article{1afc32ac9da547578f4d5ab47917f388,

title = "Lung Diseases of the Elderly: Cellular Mechanisms",

abstract = "Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.",

keywords = "Aging, Cellular senescence, COPD, Idiopathic pulmonary fibrosis, Stem cells",

author = "Kori Ascher and Sharon Elliot and Rubio, {Gustavo A.} and {Glassberg Csete}, {Marilyn K}",

year = "2017",

month = nov,

day = "1",

doi = "10.1016/j.cger.2017.07.001",

language = "English (US)",

volume = "33",

pages = "473--490",

journal = "Clinics in Geriatric Medicine",

issn = "0749-0690",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Lung Diseases of the Elderly

T2 - Cellular Mechanisms

AU - Ascher, Kori

AU - Elliot, Sharon

AU - Rubio, Gustavo A.

AU - Glassberg Csete, Marilyn K

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

AB - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

KW - Aging

KW - Cellular senescence

KW - COPD

KW - Idiopathic pulmonary fibrosis

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85027568201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027568201&partnerID=8YFLogxK

U2 - 10.1016/j.cger.2017.07.001

DO - 10.1016/j.cger.2017.07.001

M3 - Review article

C2 - 28991645

AN - SCOPUS:85027568201

VL - 33

SP - 473

EP - 490

JO - Clinics in Geriatric Medicine

JF - Clinics in Geriatric Medicine

SN - 0749-0690

IS - 4

ER -