Lung development in the streptozotocin rat fetus: Antioxidant enzymes and survival in high oxygen

Ilene R.S. Sosenko, Lee Frank

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Offspring of experimentally induced diabetic animals demonstrated delays in functional, biochemical, and morphological aspects of lung maturation, dealing mainly with the surfactant system. To investigate whether the development of the lung antioxidant enzyme system would be similarly delayed, and thus compromise their tolerance to high O2 exposure, we did the following: 1) produced the diabetic state in rats with streptozotocin injection 24 h after the onset of pregnancy; 2) examined fetal animals from streptozotocin and control rats at gestational days 19, 20, and 21, and newborn animals at day 22 for whole lung disaturated phosphatidylcholine and total phospholipid and for the three antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, and 3) exposed newborn offspring from streptozotocin-treated and control rats to >95% O2 for several days and their survival, changes in antioxidant enzymes and disaturated phosphatidylcholine and light microscopic findings in response to hyperoxic challenge were compared. Streptozotocin offspring demonstrated essentially no developmental differences in whole lung disaturated phosphatidylcholine, total phospholipid, or antioxidant enzymes activity at the 4 gestational days studied. However, newborns of streptozotocin mothers had consistently superior tolerance to hyperoxic exposure, consisting of increased survival [23/34 (68%) versus 8/26 (31%) in controls, after O2-exposure for 13 days, p < 0.001], microscopic evidence of reduced inhibition of alveolarization (p < 0.05), and a trend toward greater antioxidant enzymes response. Thus, in this animal model of experimental diabetes, neither the development of the antioxidant enzymes system nor the development of the surfactant system (as assessed by whole lung disaturated phosphatidylcholine and total phospholipid) appear delayed. However, the superior tolerance to hyperoxic exposure in streptozotocin offspring raises the question whether maternal diabetes might actually have a protective influence against O2-induced lung damage in prematurely delivered infants of diabetic mothers.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalPediatric Research
Issue number1
StatePublished - Jan 1986

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Lung development in the streptozotocin rat fetus: Antioxidant enzymes and survival in high oxygen'. Together they form a unique fingerprint.

Cite this