TY - JOUR
T1 - Câncer de pulmão no Brasil
AU - Grupo Brasileiro de Oncologia Torácica
AU - Araujo, Luiz Henrique
AU - Baldotto, Clarissa
AU - De Castro, Gilberto
AU - Katz, Artur
AU - Ferreira, Carlos Gil
AU - Mathias, Clarissa
AU - Mascarenhas, Eldsamira
AU - Lopes, Gilberto de Lima
AU - Carvalho, Heloisa
AU - Tabacof, Jaques
AU - Martínez-Mesa, Jeovany
AU - Viana, Luciano de Souza
AU - Cruz, Marcelo de Souza
AU - Zukin, Mauro
AU - De Marchi, Pedro
AU - Terra, Ricardo Mingarini
AU - Ribeiro, Ronaldo Albuquerque
AU - De Lima, Vladmir Cláudio Cordeiro
AU - Werutsky, Gustavo
AU - Barrios, Carlos Henrique
N1 - Funding Information:
Some efforts have been made to compile data on the frequency of molecular abnormalities in Brazilian patients (Table 2).(40-48) Overall, the data suggest that the frequency of EGFR mutations is lower in Brazil (approximately 25%) than in Asia but higher than in White populations in North America and Europe (Figure 3), confirming findings from other Latin American countries.(49) It has been speculated that the ethnic background could be responsible for the distinct molecular profile seen in these instances, perhaps due to the characteristic genetic admixture seen in Brazilians, inherited from European, African, and Native American ancestors. The frequency of ALK translocations has been reported to range from 3% to 4%.(48,50,51) To explore these points in a better way, two multicenter studies have been initiated, led by the Brazilian National Clinical Cancer Research Network and the Latin American Cooperative Oncology Group. These consortiums are supported by pharmaceutical companies, as well as by North American societies, such as the American Society of Clinical Oncology and the American Association for Cancer Research.
Publisher Copyright:
© 2018 Sociedade Brasileira de Pneumologia e Tisiologia.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Lung cancer is one of the most incident types of cancer and a leading cause of cancer mortality in Brazil. We reviewed the current status of lung cancer by searching relevant data on prevention, diagnosis, and treatment in the country. This review highlights several issues that need to be addressed, including smoking control, patient lack of awareness, late diagnosis, and disparities in the access to cancer health care facilities in Brazil. We propose strategies to help overcome these limitations and challenge health care providers, as well as the society and governmental representatives, to work together and to take a step forward in fighting lung cancer.
AB - Lung cancer is one of the most incident types of cancer and a leading cause of cancer mortality in Brazil. We reviewed the current status of lung cancer by searching relevant data on prevention, diagnosis, and treatment in the country. This review highlights several issues that need to be addressed, including smoking control, patient lack of awareness, late diagnosis, and disparities in the access to cancer health care facilities in Brazil. We propose strategies to help overcome these limitations and challenge health care providers, as well as the society and governmental representatives, to work together and to take a step forward in fighting lung cancer.
KW - Biomarkers
KW - Brazil
KW - Lung neoplasms/ diagnosis
KW - Lung neoplasms/epidemiology
KW - Lung neoplasms/therapy
UR - http://www.scopus.com/inward/record.url?scp=85043785765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043785765&partnerID=8YFLogxK
U2 - 10.1590/s1806-37562017000000135
DO - 10.1590/s1806-37562017000000135
M3 - Review article
C2 - 29538545
AN - SCOPUS:85043785765
VL - 44
SP - 55
EP - 64
JO - Jornal Brasileiro de Pneumologia
JF - Jornal Brasileiro de Pneumologia
SN - 1806-3713
IS - 1
ER -