Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Yuan Yuan Huang, Ye Tian, Xiao Qin Liu, Zhongwei Niu, Qing Zheng Yang, Vaidhyanathan Ramamurthy, Chen Ho Tung, Yu Zhe Chen, Li Zhu Wu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

Original languageEnglish (US)
Pages (from-to)1893-1899
Number of pages7
JournalMaterials Chemistry Frontiers
Volume2
Issue number10
DOIs
StatePublished - Oct 1 2018

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Polymers
Nanoparticles
Imaging techniques
Nanoprobes
Phosphorescence
Photodynamic therapy
Oxygen
Cells
Singlet Oxygen
Porphyrins
Energy transfer
Hydrogen
Hydrogen bonds

ASJC Scopus subject areas

  • Materials Chemistry
  • Materials Science(all)

Cite this

Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy. / Huang, Yuan Yuan; Tian, Ye; Liu, Xiao Qin; Niu, Zhongwei; Yang, Qing Zheng; Ramamurthy, Vaidhyanathan; Tung, Chen Ho; Chen, Yu Zhe; Wu, Li Zhu.

In: Materials Chemistry Frontiers, Vol. 2, No. 10, 01.10.2018, p. 1893-1899.

Research output: Contribution to journalArticle

Huang, Yuan Yuan ; Tian, Ye ; Liu, Xiao Qin ; Niu, Zhongwei ; Yang, Qing Zheng ; Ramamurthy, Vaidhyanathan ; Tung, Chen Ho ; Chen, Yu Zhe ; Wu, Li Zhu. / Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy. In: Materials Chemistry Frontiers. 2018 ; Vol. 2, No. 10. pp. 1893-1899.
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AU - Ramamurthy, Vaidhyanathan

AU - Tung, Chen Ho

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