Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Yuan Yuan Huang, Ye Tian, Xiao Qin Liu, Zhongwei Niu, Qing Zheng Yang, Vaidhyanathan Ramamurthy, Chen Ho Tung, Yu Zhe Chen, Li Zhu Wu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs), serving as a ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment, were designed. Herein, oxygen-sensitive phosphorescent Pt(ii) porphyrin moiety and oxygen-insensitive fluorescent 9,10-diphenylanthracene moiety were assembled through quadruple hydrogen bonding into SPNPs. The efficient energy transfer between the monomeric donor-acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetimes. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of a multi-functional supramolecular polymer-based nanoprobe for ratiometric hypoxia sensing, imaging and PDT treatment.

Original languageEnglish (US)
Pages (from-to)1893-1899
Number of pages7
JournalMaterials Chemistry Frontiers
Volume2
Issue number10
DOIs
StatePublished - Oct 1 2018

ASJC Scopus subject areas

  • Materials Chemistry
  • Materials Science(all)

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