Lowering apolipoprotein CIII delays onset of type 1 diabetes

Rebecka Holmberg; Essam Refai; Anders Höög; Rosanne M. Crooke; Mark Graham; Gunilla Olivecrona; Per Olof Berggren; Lisa Juntti-Berggren

doi:10.1073/pnas.1019553108

Lowering apolipoprotein CIII delays onset of type 1 diabetes

Rebecka Holmberg, Essam Refai, Anders Höög, Rosanne M. Crooke, Mark Graham, Gunilla Olivecrona, Per Olof Berggren, Lisa Juntti-Berggren

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Abstract

Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.

Original language	English (US)
Pages (from-to)	10685-10689
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	108
Issue number	26
DOIs	https://doi.org/10.1073/pnas.1019553108
State	Published - Jun 28 2011

Keywords

β-cell destruction
BB rat model
Cytoplasmic free Ca concentration
Diabetes onset
Insulin release

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.1019553108

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Lowering apolipoprotein CIII delays onset of type 1 diabetes. / Holmberg, Rebecka; Refai, Essam; Höög, Anders; Crooke, Rosanne M.; Graham, Mark; Olivecrona, Gunilla; Berggren, Per Olof; Juntti-Berggren, Lisa.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 26, 28.06.2011, p. 10685-10689.

Research output: Contribution to journal › Article › peer-review

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abstract = "Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.",

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AU - Olivecrona, Gunilla

AU - Berggren, Per Olof

AU - Juntti-Berggren, Lisa

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AB - Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.

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Lowering apolipoprotein CIII delays onset of type 1 diabetes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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