Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: A nested case-control study

E. D. Gorham, C. F. Garland, A. A. Burgi, S. B. Mohr, K. Zeng, H. Hofflich, J. J. Kim, Camillo Ricordi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (ptrend >0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were >43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≤100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≤60 nmol/l.

Original languageEnglish
Pages (from-to)3224-3227
Number of pages4
JournalDiabetologia
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2012

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Case-Control Studies
Insulin
Serum
Matched-Pair Analysis
25-hydroxyvitamin D
Logistic Models

Keywords

  • 25-Hydroxyvitamin D
  • Insulin-requiring diabetes
  • Military populations
  • Nested case-control study
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes : A nested case-control study. / Gorham, E. D.; Garland, C. F.; Burgi, A. A.; Mohr, S. B.; Zeng, K.; Hofflich, H.; Kim, J. J.; Ricordi, Camillo.

In: Diabetologia, Vol. 55, No. 12, 01.12.2012, p. 3224-3227.

Research output: Contribution to journalArticle

Gorham, E. D. ; Garland, C. F. ; Burgi, A. A. ; Mohr, S. B. ; Zeng, K. ; Hofflich, H. ; Kim, J. J. ; Ricordi, Camillo. / Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes : A nested case-control study. In: Diabetologia. 2012 ; Vol. 55, No. 12. pp. 3224-3227.
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abstract = "Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95{\%} CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (ptrend >0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were >43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≤100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≤60 nmol/l.",
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T2 - A nested case-control study

AU - Gorham, E. D.

AU - Garland, C. F.

AU - Burgi, A. A.

AU - Mohr, S. B.

AU - Zeng, K.

AU - Hofflich, H.

AU - Kim, J. J.

AU - Ricordi, Camillo

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AB - Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (ptrend >0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were >43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≤100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≤60 nmol/l.

KW - 25-Hydroxyvitamin D

KW - Insulin-requiring diabetes

KW - Military populations

KW - Nested case-control study

KW - Type 1 diabetes mellitus

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