TY - JOUR
T1 - Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes
T2 - A nested case-control study
AU - Gorham, E. D.
AU - Garland, C. F.
AU - Burgi, A. A.
AU - Mohr, S. B.
AU - Zeng, K.
AU - Hofflich, H.
AU - Kim, J. J.
AU - Ricordi, C.
N1 - Funding Information:
Funding This research was supported by a Congressional allocation to the University of Miami Diabetes Research Institute (Miami, FL, USA), through the Department of the Navy, Bureau of Medicine and Surgery, under Work Unit No. 60126. The views expressed in this report are those of the authors and do not represent an official position of the Department of the Navy, Department of Defense, or the US Government.
PY - 2012/12
Y1 - 2012/12
N2 - Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (ptrend >0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were >43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≤100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≤60 nmol/l.
AB - Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes. Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (ptrend >0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were >43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≤100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≤60 nmol/l.
KW - 25-Hydroxyvitamin D
KW - Insulin-requiring diabetes
KW - Military populations
KW - Nested case-control study
KW - Type 1 diabetes mellitus
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U2 - 10.1007/s00125-012-2709-8
DO - 10.1007/s00125-012-2709-8
M3 - Article
C2 - 22955995
AN - SCOPUS:84868204387
VL - 55
SP - 3224
EP - 3227
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 12
ER -
