Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya

Weidong Gu, Charles M. Mbogo, John I. Githure, James L. Regens, Gerry F. Killeen, Chris M. Swalm, Guiyun Yan, John C Beier

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The prevalence of Plasmodium falciparum malaria in African communities can be high and stable even in areas of relatively low transmission where people expose to only a few infectious bites per year. We show in this field study conducted in 30 sites along the coastal Kenya that prevalence in school children was consistently high, although there were many sites where transmission intensity measured by exposure to infectious bites was less than 10 per year. Statistical analyses revealed that prevalence was significantly correlated with the infectious exposure occurring 10-11 months previously, suggesting that long-lived infections were commonplace and one of the major contributors for the stability of malaria in these sites. Using mechanistic models of malaria transmission, we found that the association of high prevalence and low transmission could be due to low recovery rates. Therefore, significant reductions of malaria prevalence and burden require substantial reductions of the duration of acquired infections, even in areas that have quite low transmission intensities by the standards of sub-Saharan Africa. Infection control featured by active detection and drug treatment as well as vector control is critical to combat malaria in areas of relatively low transmission intensity.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalActa Tropica
Volume86
Issue number1
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Fingerprint

Kenya
malaria
Malaria
indigenous species
Bites and Stings
school children
vector control
Falciparum Malaria
Africa South of the Sahara
mechanistic models
Plasmodium falciparum
Sub-Saharan Africa
Infection Control
Infection
infection
drug therapy
disease control
duration
Pharmaceutical Preparations

Keywords

  • Case detection and drug treatment
  • Epidemiology
  • Infection control
  • Logistic regression
  • Model

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya. / Gu, Weidong; Mbogo, Charles M.; Githure, John I.; Regens, James L.; Killeen, Gerry F.; Swalm, Chris M.; Yan, Guiyun; Beier, John C.

In: Acta Tropica, Vol. 86, No. 1, 01.04.2003, p. 71-81.

Research output: Contribution to journalArticle

Gu, W, Mbogo, CM, Githure, JI, Regens, JL, Killeen, GF, Swalm, CM, Yan, G & Beier, JC 2003, 'Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya', Acta Tropica, vol. 86, no. 1, pp. 71-81. https://doi.org/10.1016/S0001-706X(03)00020-2
Gu, Weidong ; Mbogo, Charles M. ; Githure, John I. ; Regens, James L. ; Killeen, Gerry F. ; Swalm, Chris M. ; Yan, Guiyun ; Beier, John C. / Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya. In: Acta Tropica. 2003 ; Vol. 86, No. 1. pp. 71-81.
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