Low morbidity associated with use of N-butyl cyanoacrylate liquid adhesive for preoperative transarterial embolization of central nervous system tumors

Louis J. Kim, Felipe C. Albuquerque, Ali Aziz-Sultan, Robert F. Spetzler, Cameron G. McDougall

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE: To determine the safety and efficacy of preoperative embolization of central nervous system tumors with n-butyl cyanoacrylate (NBCA) liquid adhesive. METHODS: Over a 6-year period, 35 consecutive patients (12 women, 23 men; mean age, 42 yr; range, 6 mo-75 yr) with a central nervous system tumor underwent preoperative embolization with NBCA. Tumor type, location, endovascular and surgical treatment, percent of tumor embolization, estimated blood loss, and neurological deficits related to embolization were evaluated retrospectively. RESULTS: One hundred feeding arteries were embolized (mean, 3 vessels/patient). In only one (3%) case was a normal artery inadvertently occluded by the embolization. During the follow-up period, the resulting neurological deficit resolved completely. There were no neurological deficits or inadvertent embolization events in the remaining 34 cases. The mean percent of tumor embolized was 68%, but this did not significantly correlate with operative blood loss (Pearson's correlation coefficient, r = 0.049). CONCLUSION: In experienced hands, central nervous system tumors can be embolized with NBCA liquid adhesive with a high degree of safety and efficacy. We think that adroit embolization technique with NBCA and other embolisates should be part of the contemporary neuroendovascular armamentarium.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalNeurosurgery
Volume59
Issue number1
DOIs
StatePublished - Jul 1 2006

Fingerprint

Enbucrilate
Cyanoacrylates
Central Nervous System Neoplasms
Adhesives
Morbidity
Arteries
Safety
Neoplasms

Keywords

  • Brain tumor
  • Endovascular treatment
  • N-Butyl cyanoacrylate
  • Polyvinyl alcohol
  • Preoperative transarterial embolization
  • Spine tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Low morbidity associated with use of N-butyl cyanoacrylate liquid adhesive for preoperative transarterial embolization of central nervous system tumors. / Kim, Louis J.; Albuquerque, Felipe C.; Aziz-Sultan, Ali; Spetzler, Robert F.; McDougall, Cameron G.

In: Neurosurgery, Vol. 59, No. 1, 01.07.2006, p. 98-103.

Research output: Contribution to journalArticle

Kim, Louis J. ; Albuquerque, Felipe C. ; Aziz-Sultan, Ali ; Spetzler, Robert F. ; McDougall, Cameron G. / Low morbidity associated with use of N-butyl cyanoacrylate liquid adhesive for preoperative transarterial embolization of central nervous system tumors. In: Neurosurgery. 2006 ; Vol. 59, No. 1. pp. 98-103.
@article{d692dfa755784eae9450d04eb4c0cf42,
title = "Low morbidity associated with use of N-butyl cyanoacrylate liquid adhesive for preoperative transarterial embolization of central nervous system tumors",
abstract = "OBJECTIVE: To determine the safety and efficacy of preoperative embolization of central nervous system tumors with n-butyl cyanoacrylate (NBCA) liquid adhesive. METHODS: Over a 6-year period, 35 consecutive patients (12 women, 23 men; mean age, 42 yr; range, 6 mo-75 yr) with a central nervous system tumor underwent preoperative embolization with NBCA. Tumor type, location, endovascular and surgical treatment, percent of tumor embolization, estimated blood loss, and neurological deficits related to embolization were evaluated retrospectively. RESULTS: One hundred feeding arteries were embolized (mean, 3 vessels/patient). In only one (3{\%}) case was a normal artery inadvertently occluded by the embolization. During the follow-up period, the resulting neurological deficit resolved completely. There were no neurological deficits or inadvertent embolization events in the remaining 34 cases. The mean percent of tumor embolized was 68{\%}, but this did not significantly correlate with operative blood loss (Pearson's correlation coefficient, r = 0.049). CONCLUSION: In experienced hands, central nervous system tumors can be embolized with NBCA liquid adhesive with a high degree of safety and efficacy. We think that adroit embolization technique with NBCA and other embolisates should be part of the contemporary neuroendovascular armamentarium.",
keywords = "Brain tumor, Endovascular treatment, N-Butyl cyanoacrylate, Polyvinyl alcohol, Preoperative transarterial embolization, Spine tumor",
author = "Kim, {Louis J.} and Albuquerque, {Felipe C.} and Ali Aziz-Sultan and Spetzler, {Robert F.} and McDougall, {Cameron G.}",
year = "2006",
month = "7",
day = "1",
doi = "10.1227/01.NEU.0000220215.71485.07",
language = "English",
volume = "59",
pages = "98--103",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Low morbidity associated with use of N-butyl cyanoacrylate liquid adhesive for preoperative transarterial embolization of central nervous system tumors

AU - Kim, Louis J.

AU - Albuquerque, Felipe C.

AU - Aziz-Sultan, Ali

AU - Spetzler, Robert F.

AU - McDougall, Cameron G.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - OBJECTIVE: To determine the safety and efficacy of preoperative embolization of central nervous system tumors with n-butyl cyanoacrylate (NBCA) liquid adhesive. METHODS: Over a 6-year period, 35 consecutive patients (12 women, 23 men; mean age, 42 yr; range, 6 mo-75 yr) with a central nervous system tumor underwent preoperative embolization with NBCA. Tumor type, location, endovascular and surgical treatment, percent of tumor embolization, estimated blood loss, and neurological deficits related to embolization were evaluated retrospectively. RESULTS: One hundred feeding arteries were embolized (mean, 3 vessels/patient). In only one (3%) case was a normal artery inadvertently occluded by the embolization. During the follow-up period, the resulting neurological deficit resolved completely. There were no neurological deficits or inadvertent embolization events in the remaining 34 cases. The mean percent of tumor embolized was 68%, but this did not significantly correlate with operative blood loss (Pearson's correlation coefficient, r = 0.049). CONCLUSION: In experienced hands, central nervous system tumors can be embolized with NBCA liquid adhesive with a high degree of safety and efficacy. We think that adroit embolization technique with NBCA and other embolisates should be part of the contemporary neuroendovascular armamentarium.

AB - OBJECTIVE: To determine the safety and efficacy of preoperative embolization of central nervous system tumors with n-butyl cyanoacrylate (NBCA) liquid adhesive. METHODS: Over a 6-year period, 35 consecutive patients (12 women, 23 men; mean age, 42 yr; range, 6 mo-75 yr) with a central nervous system tumor underwent preoperative embolization with NBCA. Tumor type, location, endovascular and surgical treatment, percent of tumor embolization, estimated blood loss, and neurological deficits related to embolization were evaluated retrospectively. RESULTS: One hundred feeding arteries were embolized (mean, 3 vessels/patient). In only one (3%) case was a normal artery inadvertently occluded by the embolization. During the follow-up period, the resulting neurological deficit resolved completely. There were no neurological deficits or inadvertent embolization events in the remaining 34 cases. The mean percent of tumor embolized was 68%, but this did not significantly correlate with operative blood loss (Pearson's correlation coefficient, r = 0.049). CONCLUSION: In experienced hands, central nervous system tumors can be embolized with NBCA liquid adhesive with a high degree of safety and efficacy. We think that adroit embolization technique with NBCA and other embolisates should be part of the contemporary neuroendovascular armamentarium.

KW - Brain tumor

KW - Endovascular treatment

KW - N-Butyl cyanoacrylate

KW - Polyvinyl alcohol

KW - Preoperative transarterial embolization

KW - Spine tumor

UR - http://www.scopus.com/inward/record.url?scp=33745767794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745767794&partnerID=8YFLogxK

U2 - 10.1227/01.NEU.0000220215.71485.07

DO - 10.1227/01.NEU.0000220215.71485.07

M3 - Article

C2 - 16823305

AN - SCOPUS:33745767794

VL - 59

SP - 98

EP - 103

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 1

ER -