Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children

Martina Huemer, Burkhard Simma, Dieter Mayr, Adolf Mühl, Birgit Rami, Edith Schober, Hanno Ulmer, Ulrike Zanier, Olaf A. Bodamer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: Although high levels of asymmetric dimethylarginine (ADMA) are associated with an increased risk for vasculopathy in adults, elevated ADMA concentrations also have been found in healthy young children. Patients with diabetes mellitus type 1 (DM1) are at risk for vasculopathy, and because the function of ADMA in the development of vascular symptoms is incompletely understood, we investigated ADMA concentrations in pediatric patients with DM1 compared with healthy age- and sex-matched individuals. Study design: This cross-sectional study included 85 pediatric patients with DM1 and 89 age- and sex-matched healthy controls. Results: ADMA concentrations were significantly lower in the patients with DM1 and were inversely correlated with hemoglobin A1c concentrations. Conclusions: Besides its vasoprotective function, nitric oxide itself may exert oxidative stress by generating free radicals. In these circumstances, ADMA would protect the system from nitric oxide overproduction and perpetuation of oxidative stress. This theory is supported by the physiologically higher ADMA concentrations in healthy children. Thus, low ADMA concentrations in children with DM1 may be an indicator of impaired protection against oxidative stress.

Original languageEnglish
JournalJournal of Pediatrics
Volume158
Issue number4
DOIs
StatePublished - Apr 1 2011

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Type 1 Diabetes Mellitus
Oxidative Stress
Nitric Oxide
Pediatrics
N,N-dimethylarginine
Free Radicals
Blood Vessels
Hemoglobins
Cross-Sectional Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children. / Huemer, Martina; Simma, Burkhard; Mayr, Dieter; Mühl, Adolf; Rami, Birgit; Schober, Edith; Ulmer, Hanno; Zanier, Ulrike; Bodamer, Olaf A.

In: Journal of Pediatrics, Vol. 158, No. 4, 01.04.2011.

Research output: Contribution to journalArticle

Huemer, M, Simma, B, Mayr, D, Mühl, A, Rami, B, Schober, E, Ulmer, H, Zanier, U & Bodamer, OA 2011, 'Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children', Journal of Pediatrics, vol. 158, no. 4. https://doi.org/10.1016/j.jpeds.2010.09.058
Huemer, Martina ; Simma, Burkhard ; Mayr, Dieter ; Mühl, Adolf ; Rami, Birgit ; Schober, Edith ; Ulmer, Hanno ; Zanier, Ulrike ; Bodamer, Olaf A. / Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children. In: Journal of Pediatrics. 2011 ; Vol. 158, No. 4.
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AU - Rami, Birgit

AU - Schober, Edith

AU - Ulmer, Hanno

AU - Zanier, Ulrike

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AB - Objective: Although high levels of asymmetric dimethylarginine (ADMA) are associated with an increased risk for vasculopathy in adults, elevated ADMA concentrations also have been found in healthy young children. Patients with diabetes mellitus type 1 (DM1) are at risk for vasculopathy, and because the function of ADMA in the development of vascular symptoms is incompletely understood, we investigated ADMA concentrations in pediatric patients with DM1 compared with healthy age- and sex-matched individuals. Study design: This cross-sectional study included 85 pediatric patients with DM1 and 89 age- and sex-matched healthy controls. Results: ADMA concentrations were significantly lower in the patients with DM1 and were inversely correlated with hemoglobin A1c concentrations. Conclusions: Besides its vasoprotective function, nitric oxide itself may exert oxidative stress by generating free radicals. In these circumstances, ADMA would protect the system from nitric oxide overproduction and perpetuation of oxidative stress. This theory is supported by the physiologically higher ADMA concentrations in healthy children. Thus, low ADMA concentrations in children with DM1 may be an indicator of impaired protection against oxidative stress.

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