Low-level Plasmodium falciparum transmission and the incidence of severe malaria infections on the Kenyan coast

C. N M Mbogo, R. W. Snow, E. W. Kabiru, J. H. Ouma, J. I. Githure, K. Marsh, John C Beier

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Abstract

The transmission of Plasmodium falciparum was studied in relation to the incidence of severe malaria infections at Sokoke and Kilifi town, Kilifi District, Kenya. Intensive mosquito sampling during a one-year period yielded Anopheles gambiae s.l., An. funestus, and An. coustani. Anopheles gambiae s.l. was the predominant vector, comprising 87.9% and 97.9% of the total anophelines collected in Sokoke and Kilifi town, respectively. The proportion of An. gambiae s.l. with P. falciparum sporozoite infections was 4.1% (20 of 491) in Sokoke and 2.2% (3 of 138) in Kilifi town; no infections were detected in An. funestus or in An. coustani. Entomologic inoculation rates indicated that residents were exposed to only 8.0 infective bites per year in Sokoke and 1.5 in Kilifi town. Transmission was detected during only six months in Sokoke and three months in Kilifi town despite low-level, year- round vector activity. The yearly incidence of severe P. falciparum infections in children, 1-4 years of age was 24.1 per 1,000 in Sokoke and 4.2 per 1,000 in Kilifi town. Monthly patterns of transmission corresponded closely with the incidence of severe infections. At these sites on the coast of Kenya, the spatial and temporal incidence of severe malaria infections is associated with low-level P. falciparum transmission by vector populations.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume49
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes

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Plasmodium falciparum
Malaria
Anopheles gambiae
Incidence
Infection
Kenya
Sporozoites
Bites and Stings
Culicidae
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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Low-level Plasmodium falciparum transmission and the incidence of severe malaria infections on the Kenyan coast. / Mbogo, C. N M; Snow, R. W.; Kabiru, E. W.; Ouma, J. H.; Githure, J. I.; Marsh, K.; Beier, John C.

In: American Journal of Tropical Medicine and Hygiene, Vol. 49, No. 2, 01.01.1993, p. 245-253.

Research output: Contribution to journalArticle

Mbogo, C. N M ; Snow, R. W. ; Kabiru, E. W. ; Ouma, J. H. ; Githure, J. I. ; Marsh, K. ; Beier, John C. / Low-level Plasmodium falciparum transmission and the incidence of severe malaria infections on the Kenyan coast. In: American Journal of Tropical Medicine and Hygiene. 1993 ; Vol. 49, No. 2. pp. 245-253.
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