Low HDL cholesterol but not high LDL cholesterol is independently associated with subclinical coronary atherosclerosis in healthy octogenarians

Wladimir M. Freitas, Luiz A. Quaglia, Simone N. Santos, Rafaela C S de Paula, Raul D. Santos, Michael Blaha, Juan J. Rivera, Ricardo Cury, Roger Blumenthal, Wilson Nadruz-Junior, Arthur Agatston, Valeria N. Figueiredo, Khurram Nasir, Andrei C. Sposito

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Aim of the study: Although low-density lipoprotein cholesterol (LDL-C) has been consistently demonstrated a predictor of atherosclerotic disease in a large spectrum of clinical settings, among individuals aged of 80 years or older this concept is uncertain. This study was evaluated in a carefully selected population if the association between LDL-C and coronary atherosclerotic burden remains significant in the very elderly.Methods: Individuals aged of 80 years or older (n = 208) who spontaneously sought primary prevention care and have never manifested cardiovascular disease, malnutrition, neoplastic or consumptive disease were enrolled for a cross-sectional analysis. Medical evaluation, anthropometric measurements, blood tests and cardiac computed tomography were obtained.Results: In analyses adjusted for age, gender, diabetes, systolic and diastolic blood pressure, smoking and statin therapy, no association was found between coronary calcium score (CCS) and LDL-C [1.79 (0.75–4.29)]. There was no association between triglycerides and CCS. The association between high-density lipoprotein cholesterol (HDL-C) and CCS was significant and robust in unadjusted [0.32 (0.15–0.67)] as well as in the fully adjusted analysis [0.34 (0.15–0.75)].Conclusion: The present study confirms in a healthy cohort of individuals aged of 80 years or more that while the association between LDL-C and coronary atherosclerosis weakens with aging, the opposite occurs with the levels of HDL-C.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalAging - Clinical and Experimental Research
Volume27
Issue number1
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Keywords

  • Coronary calcium score
  • HDL cholesterol
  • LDL cholesterol
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Freitas, W. M., Quaglia, L. A., Santos, S. N., de Paula, R. C. S., Santos, R. D., Blaha, M., Rivera, J. J., Cury, R., Blumenthal, R., Nadruz-Junior, W., Agatston, A., Figueiredo, V. N., Nasir, K., & Sposito, A. C. (2015). Low HDL cholesterol but not high LDL cholesterol is independently associated with subclinical coronary atherosclerosis in healthy octogenarians. Aging - Clinical and Experimental Research, 27(1), 61-67. https://doi.org/10.1007/s40520-014-0249-4