Low-grade fibromyxoid sarcoma

A brief review

Stephen E. Vernon, Pablo A. Bejarano

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Low-grade fibromyxoid sarcomas are uncommon deep soft tissue neoplasms first described by Evans in 1987. They exhibit a deceptively benign appearance, with a whorled or linear arrangement of spindle-shaped cells showing few to absent mitoses. A characteristic, but not specific, feature is the presence of areas of myxoid stroma. Recurrences are common, and late metastases have been recorded. A closely related but morphologically distinct tumor, the so-called hyalinizing spindle cell tumor with giant rosettes, has also been described; both neoplasms share the same cytogenetic abnormality, a balanced translocation resulting in a FUS/CREB3L2 fusion gene. Because of similar clinical behavior and the common cytogenetic abnormality, some authors prefer to consider both lesions as a single entity within the spectrum of low-grade sarcomas.

Original languageEnglish
Pages (from-to)1358-1360
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number9
StatePublished - Sep 1 2006

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Chromosome Aberrations
Sarcoma
Soft Tissue Neoplasms
Giant Cell Tumors
Gene Fusion
Mitosis
Neoplasms
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Vernon, S. E., & Bejarano, P. A. (2006). Low-grade fibromyxoid sarcoma: A brief review. Archives of Pathology and Laboratory Medicine, 130(9), 1358-1360.

Low-grade fibromyxoid sarcoma : A brief review. / Vernon, Stephen E.; Bejarano, Pablo A.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 9, 01.09.2006, p. 1358-1360.

Research output: Contribution to journalArticle

Vernon, SE & Bejarano, PA 2006, 'Low-grade fibromyxoid sarcoma: A brief review', Archives of Pathology and Laboratory Medicine, vol. 130, no. 9, pp. 1358-1360.
Vernon, Stephen E. ; Bejarano, Pablo A. / Low-grade fibromyxoid sarcoma : A brief review. In: Archives of Pathology and Laboratory Medicine. 2006 ; Vol. 130, No. 9. pp. 1358-1360.
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