Low doses of liquorice can induce hypertension encephalopathy

S. Russo, M. Mastropasqua, M. A. Mosetti, C. Persegani, A. Paggi

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Prolonged ingestion of liquorice is a well-known cause of hypertension due to hypermineralocorticoidism. We describe 2 cases of hypertension encephalopathy (in addition to the classical symptoms of hypertension, hypokalemia and suppression of the renin-aldosterone system) which resulted in pseudohyperaldosteronism syndrome due to the regular daily intake of low doses of liquorice. Glycyrrhizic acid, a component of liquorice, produces both hypermineralocorticism and the onset of encephalopathy through the inhibition of 11β-hydroxysteroid dehydrogenase. Hypertension encephalopathy due to the daily intake of low doses of liquorice, however, has not been previously documented. It is proposed that some people could be susceptible to low doses of glycyrrhizic acid because of a 11β-hydroxysteroid dehydrogenase deficiency. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalAmerican Journal of Nephrology
Issue number2
StatePublished - 2000
Externally publishedYes


  • 11β-hydroxysteroid dehydrogenase deficiency glycyrrhizic acid
  • Encephalopathy
  • Hypertension
  • Liquorice

ASJC Scopus subject areas

  • Nephrology


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