Low-dose, titratable interferon alfa in decompensated liver disease caused by chronic infection with hepatitis B virus

Robert Perrillo, Carlo Tamburro, Fredric Regenstein, Luis Balart, Henry Bodenheimer, Marcelo Silva, Eugene Schiff, Carol Bodicky, Barbara Miller, Cheryl Denham, Carmel Brodeur, Kathy Roach, Janice Albrecht

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

Background & Aims: Interferon therapy has been associated with a number of severe side effects when administered to patients with decompensated cirrhosis caused by chronic hepatitis B. The safety and potential efficacy of a low-dose, titratable regimen of interferon alfa-2b in patients with decompensated liver disease caused by chronic hepatitis B virus infection were studied. Methods: Twenty-six patients were treated at five medical centers. Five patients had Child's class A status, 15 had Child's B status, and 6 had Child's C status. Treatment was continued for 24 weeks whenever possible. Dose adjustments were made according to predefined safety criteria. Results: All patients with Child's A status responded with a sustained loss of serum hepatitis B virus DNA, reduction in aminotransferase activity, and clinical stabilization. Only 5 patients with Child's B (33%) and no patients with Child's C status reached similar end points. The probability of survival was greater in responders than in nonresponders (P = 0.017). Three patients each developed serious infections or greater than twofold increases in serum aminotransferase levels during therapy. Conclusions: Low-dose, titratable interferon therapy is safer than previously reported regimens. Nonetheless, serious infections were observed relatively frequently, and this therapy should be reserved for individuals with mild to moderate hepatic decompensation, preferably patients with Child's A status.

Original languageEnglish (US)
Pages (from-to)908-916
Number of pages9
JournalGastroenterology
Volume109
Issue number3
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Perrillo, R., Tamburro, C., Regenstein, F., Balart, L., Bodenheimer, H., Silva, M., Schiff, E., Bodicky, C., Miller, B., Denham, C., Brodeur, C., Roach, K., & Albrecht, J. (1995). Low-dose, titratable interferon alfa in decompensated liver disease caused by chronic infection with hepatitis B virus. Gastroenterology, 109(3), 908-916. https://doi.org/10.1016/0016-5085(95)90401-8