Low-Dose Hyper-Radiosensitivity: Past, Present, and Future

Brian Marples, Spencer J. Collis

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


This review article discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to the molecular regulation of DNA repair and cell cycle control processes. Particular attention is paid to the significance of G2-phase cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying hypothesis concerning the molecular control and regulation of this important low dose radiation response. Finally, preclinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain.

Original languageEnglish (US)
Pages (from-to)1310-1318
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number5
StatePublished - Apr 1 2008
Externally publishedYes


  • Cell cycle arrest
  • DNA repair
  • Hyper-radiosensitivity
  • Ionizing radiation
  • Review

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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