Low-Dose Hyper-Radiosensitivity: Past, Present, and Future

Brian Marples, Spencer J. Collis

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

This review article discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to the molecular regulation of DNA repair and cell cycle control processes. Particular attention is paid to the significance of G2-phase cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying hypothesis concerning the molecular control and regulation of this important low dose radiation response. Finally, preclinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain.

Original languageEnglish (US)
Pages (from-to)1310-1318
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume70
Issue number5
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Radiation Tolerance
radiation tolerance
dosage
biology
G2 Phase Cell Cycle Checkpoints
Radiobiology
radiobiology
cycles
Cell Cycle Checkpoints
DNA Repair
deoxyribonucleic acid
History
histories
Radiation
radiation

Keywords

  • Cell cycle arrest
  • DNA repair
  • Hyper-radiosensitivity
  • Ionizing radiation
  • Review

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Low-Dose Hyper-Radiosensitivity : Past, Present, and Future. / Marples, Brian; Collis, Spencer J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 70, No. 5, 01.04.2008, p. 1310-1318.

Research output: Contribution to journalArticle

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