Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells

Brian Marples, P. Lambin, K. A. Skov, M. G. Joiner

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

This manuscript reviews the low-dose survival work using the DMIPS cell analyser that has been carried out at the Gray Laboratory in the U.K. and the British Columbia Cancer Research Centre in Canada. It describes low dose hyperradiosensitivity (HRS) detected after single doses of X-rays less than ~0·3 Gy and the subsequent increased radioresistant response (IRR) seen as the dose increases up to 1 Gy. Work is summarized from studies in V79 cells, normal human and human tumour cell lines and mutant cell lines deficient in DNA repair. The data are considered in light of the hypothesis that hyperradiosensitivity and increased radioresistance reflect the existence of an inducible protective mechanism, possibly triggered by DNA damage.

Original languageEnglish (US)
Pages (from-to)721-735
Number of pages15
JournalInternational Journal of Radiation Biology
Volume71
Issue number6
DOIs
StatePublished - Aug 2 1997
Externally publishedYes

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Radiation Tolerance
DNA Repair-Deficiency Disorders
British Columbia
Tumor Cell Line
DNA Damage
Canada
X-Rays
Cell Line
Survival
Research
Neoplasms

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells. / Marples, Brian; Lambin, P.; Skov, K. A.; Joiner, M. G.

In: International Journal of Radiation Biology, Vol. 71, No. 6, 02.08.1997, p. 721-735.

Research output: Contribution to journalArticle

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