Low dose hyper-radiosensitivity: A historical perspective

Brian Marples, Sarah A. Krueger, Spencer J. Collis, Michael C. Joiner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to radiation-induced DNA damage and cellular repair processes. Particular attention is paid to the significance of G2-phase cell cycle check-points in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying hypothesis concerning the molecular control and regulation of this important low-dose radiation response. Finally, pre-clinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain.

Original languageEnglish (US)
Title of host publicationTargeted Radionuclide Tumor Therapy
Subtitle of host publicationBiological Aspects
PublisherSpringer Netherlands
Pages329-347
Number of pages19
ISBN (Print)9781402086953
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Marples, B., Krueger, S. A., Collis, S. J., & Joiner, M. C. (2008). Low dose hyper-radiosensitivity: A historical perspective. In Targeted Radionuclide Tumor Therapy: Biological Aspects (pp. 329-347). Springer Netherlands. https://doi.org/10.1007/978-1-4020-8696-0_19